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Fermentation of trichoderma reesei and apparatus therefor

  • US 4,952,505 A
  • Filed: 08/08/1988
  • Issued: 08/28/1990
  • Est. Priority Date: 08/08/1988
  • Status: Expired due to Term
First Claim
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1. A process for producing enzyme cellulases by the fermentation of Trichoderma reesei (ATCC 26921) in an aqueous nutrient medium containing assimilable sources of cellulose, nitrogen, phosphate magnesium and iron in the presence of an oxygen containing atmosphere, the method comprisingfermenting the Trichoderma reesei at a temperature of between about 26°

  • C. and 31°

    C. while maintaining the oxygen containing atmosphere at a pressure of about 1 atmosphere until the Trichoderma reesei enter the late stationary growth phase,thereafter, gradually and steadily increasing the pressure of the oxygen containing atmosphere until it is in excess of about 7 atmospheres and fermenting the Trichoderma reesei at said increased pressure and at an increased temperature of between about 40°

    C. and about 60°

    C., thereby resulting in the production of enzyme cellulases by the Trichoderma reesei, andrecovering the enzyme cellulases.

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