Hydrodynamic clot flushing

• US 4,954,129 A
• Filed: 07/25/1988
• Issued: 09/04/1990
• Est. Priority Date: 07/25/1988
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Vurek, Gerald G., Giuliani, David
• Primary Examiner(s): Pellegrino, Stephen C.
• Application Number:
  US07/224,074
• Time in Patent Office: 771 Days
• Field of Search: 604/53, 604/52, 604/93, 604/131, 604/164, 604/266, 604/264, 128/DIG. 12, 128/4, 128/6
• US Class Current: 604/540
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
• CPC Class Codes: A61M 25/0023 by the form of the lumen, e.g. cross-section, variable diameter

Abstract

A process for flushing clots from an intravascular probe including the steps of positioning a catheter assembly in a blood vessel and then delivering a flushant through the catheter and past the probe at two rates. The flushant is first delivered at a continual rate to maintain the catheter substantially free of blood clots. Periodically, a pulse of flushant is delivered at a second flow rate that is higher than the continual rate that is effective to clear the probe of incipient clots. The hydrodynamic clot flushing system includes a cather insertable within an arterial or venous blood vessel, the cather having an internal axial bore for conducting fluid and in which a probe is slidably received. A valve delivers a flushant through the internal axial bore of the catheter and around the probe at two selected rates. A plurality of radially arrayed ribs formed on either the internal wall of the catheter or the outside of the probe or both hold the probe away from the wall and provide fluid channels for conducting flushant to the probe tip.

Claims

1. A process for flushing clots form an intravascular probe, comprising the steps of:

inserting a catheter assembly in a blood vessel, the catheter assembly comprising a catheter segment having an internal axial bore, the segment fitted substantially throughout its bore with an intravascular probe, wherein the intravascular probe does not completely occlude the internal axial bore;

delivering a flushant through the catheter bore and past the probe at a continual rate sufficient to maintain the catheter bore substantially free of blood clots; and

periodically delivering through the catheter bore a pulse of flushant at a rate that is higher than the continual rate and effective to substantially clear the probe of incipient blood clots.

2. The process of claim 1, wherein the period is in the range of from about 10 minutes to about 3 hours.

3. The process of claim 1, wherein the ratio of the continual rate to the velocity of blood flow in the blood vessel is less than about 5%.

4. The process of claim 1, wherein the flow rate of the pulse of flushant is in the range of from about 6 to about 50 times the velocity of blood in the blood vessel.

5. The process of claim 1, wherein the flow rate of the pulse of flushant is in the range of from about 100 centimeters per second to about 600 centimeters per second.

6. The process of claim 1, wherein the catheter assembly comprises a centering means on the probe or the catheter or both for centering the probe within the catheter bore and providing fluid channels radially arrayed around the probe and axially arrayed along the catheter bore.

7. The process of claim 1, wherein the probe comprises at least one optical fiber.

8. The process of claim 1, wherein the probe comprises a thermocouple wire pair.

9. A hydrodynamic clot flushing system for flushing clots from an intravascular probe, the system comprising:

a catheter means insertable within an arterial or venous blood vessel, the catheter means having an internal axial bore for conducting fluid, said bore having therein means for supporting said probe and providing a space between said probe and the bore wall of the catheter to enable fluid to pass therethrough; and

means for delivering a flushant through the internal axial bore of the catheter and past the probe at a first flow rate sufficient to maintain the internal axial bore of the catheter means substantially free of blood clots and a second flow rate that is higher than the first flow rate and effective to substantially clear the probe of incipient clots.

10. The system of claim 9, wherein the ratio of the first flow rate to the velocity of arterial or venous blood flow is less than about 5%.

11. The system of claim 9, wherein the second flow rate is in the range of from about 6 to about 50 times the velocity of blood in the blood vessel.

12. The system of claim 9, wherein the second flow rate is in the range of from about 100 centimeters per second to about 600 centimeters per second.

13. The system of claim 9, comprising means for centering the probe within the internal axial bore of the catheter means.

14. The system of claim 13, wherein the centering means comprises ribs formed on either of the probe or the catheter means or both for centering the probe within the internal axial bore and providing fluid channels radially arrayed around the probe and axially arrayed along the internal axial bore.

15. The system of claim 14, wherein the ratio of the first flow rate to the velocity of arterial or venous blood flow is less than about 5%.

16. The system of claim 14, wherein the second flow rate is in the range of from about 6 to about 50 times the velocity of blood in the blood vessel.

17. The system of claim 14, wherein the second flow rate is in the range of from about 100 centimeters per second to about 600 centimeters per second.