Ruminant dispensing device

• US 4,955,881 A
• Filed: 07/25/1989
• Issued: 09/11/1990
• Est. Priority Date: 08/16/1985
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Rafa, Michael
• Application Number:
  US07/384,613
• Time in Patent Office: 413 Days
• Field of Search: 604/890.1-892.1, 424/473, 424/469, 424/438
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (4) a passageway in the housing for delivering the beneficial agent from the dispensing device.

Claims

1. A delivery system for delivering a beneficial agent formulation to an environment of use, the delivery system comprising:

(a) a wall surrounding and forming an internal compartment, the wall comprising in at least a part of composition permeable to the passage of fluid present in the environment of use;

(b) a beneficial agent in the compartment, said beneficial agent a member selected from the group consisting of antibloat, anthelmintics, antibiotic, anti-infectious, antiparasitic, antimicrobial and anti-flea beneficial agents;

(c) exit means in the wall for connecting the internal compartment with the exterior of the delivery system for delivering the beneficial agent to the environment of use;

(d) means in the compartment for occupying an increasing amount of area in the compartment for urging the beneficial agent through the exit means in the wall for delivering the beneifical agent over time; and

,

(e) density means possessing a specific gravity greater than the specific gravity of fluid present in the environment of use present in means (d) for increasing the density of means (d).

2. A delivery system for delivering a beneficial agent to the environment of use according to claim 1, wherein the beneficial agent is mixed with a member selected from the group consisting of a glyceride of a fatty acid having a melting point of at least 31°

C., and a block copolymer of 1,2-butylene oxide and ethylene oxide.

3. A delivery system for delivering a beneficial agent to the environment of use according to claim 1, wherein the means in (d) is a member selected from the group consisting of poly(ethylene oxide), poly(acrylamide), poly(arylic acid), and poly(hydroxyalkyl acrylate).

4. A delivery system for delivering a beneficial agent to the environment of use according to claim 1, wherein the means in (d) is a hydrogel.

5. A delivery system for delivering a beneficial agent to the environment of use according to claim 1 wherein the means in (d) is a composition comprising a hydrogel and an osmotically effective solute.

6. A delivery system for delivering a beneficial agent to the environment of use according to claim 1, wherein the means in (d) is a composition comprising a hydrogel and a member selected from the group consisting of iron, steel, iron magnesium alloy, a mixture of cobalt and iron, copper oxide, iron oxide, and a mixture of copper oxide and iron.

7. A delivery system for delivering a beneficial agent to the environment of use according to claim 1, wherein the means in (d) comprises a hydrogel, an osmotically effective compound, and the density member is selected from the group consisting of iron, steel, iron magnesium alloy, a mixture of cobalt and iron, copper oxide, iron oxide, and a mixture of copper oxide and iron.

8. A delivery system for delivering a beneficial agent to the environment of use according to claim 1, wherein the beneficial agent is replaced by a member selected from the group consisting of a nutrient, feed additive, vitamin, and drug.

9. A delivery system for delivering a beneficial agent to the environment of use according to claim 1 ,wherein the beneficial agent is a member selected from the group consisting of albendazole, avermectin, cambendazole, fenbendazole, ivermectin, levamisole, morantel, mebendazole, oxybendazole, oxfendazole, parbendazole, parziquantel, thiabendazole, and techloroform.