Neural cell adhesion protein nerve prosthesis

• US 4,955,892 A
• Filed: 10/24/1988
• Issued: 09/11/1990
• Est. Priority Date: 10/24/1988
• Status: Expired due to Fees

• Current Assignee: Louisiana State University Board of Supervisors
• Original Assignee: Louisiana State University (Louisiana State University System)
• Inventors: Daniloff, Joanne K.
• Primary Examiner(s): Cannon, Alan W.
• Application Number:
  US07/261,891
• Time in Patent Office: 687 Days
• Field of Search: 623/12, 623/66, 435/1, 514/2, 530/839, 424/95, 424/108, 606/152, 606/154, 606/155
• US Class Current: 606/152
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61L 2430/32 for nerve reconstruction
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: C07K 14/475 Growth factors; Growth regulators
• CPC Class Codes: Y10S 530/839 Nerves; brain

Abstract

The neural cell adhesion molecule is used in nerve prostheses for the repair of peripheral nerve damage in mammals, both animal and man. In particular, in a process wherein a crushed or severed nerve ending is entubulated by use of a prosthetic device, a neural cell adhesion protein is added to the prosthetic device to increase the rate of growth of the fibrous components of the nerve, to more rapidly regenerate the nerve, and provide a more complete restitution of the function of the muscle served by the regenerated nerve.

Claims

1. In a process wherein the severed ends of the peripheral nerve of a living mammal, the function of which is to serve a muscle impaired by the break in the nerve, are directed via the use of an implanted prosthetic device to guide the proximate nerve end toward the distal nerve end to regenerate and repair the nerve the improvement comprising adding neural cell adhesion protein to the severed nerve ends held within said implanted prosthetic device sufficient to increase the rate of growth of the nerve vis-a-vis an implant device otherwise similar except that it does not contain said neural cell adhesion protein, to regenerate the nerve, and provide greater restitution of the muscle served by the nerve.

2. The process of claim 1 wherein the implanted prosthetic device is of tubular shape, the neural cell adhesion protein is added to the tubular opening therethrough, and to the proximate and distal nerve ends, respectively, are sutured to the ends thereof.

3. The process of claim 1 wherein the neural cell adhesion protein that is added to said implanted prosthetic device is admixed with collagen.

4. The process of claim 3 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein:

collagen ranging from about 0.1;

1 to about 10;

1.

5. The process of claim 4 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein:

collagen ranging from about 0.4;

1 to about 1;

1.

6. The process of claim 1 wherein the neural cell adhesion protein is obtained from a mammal of the same species as that in which the prosthetic device is implanted.

7. The process of claim 6 wherein the neural cell adhesion protein is obtained by extraction from the brains of a sacrificed animal.

8. The process of claim 7 wherein the neural cell adhesion protein is obtained by extraction from the brains of a sacrificed mammal of the same species as that in which the prosthetic device is implanted.

9. In a process wherein the severed ends of the peripheral nerve of a living human, the function of which is to serve a muscle impaired by the break in the nerve, are directed via the use of an implanted prosthetic device to guide the proximate nerve end toward the distal nerve end to regenerate and repair the nerve the improvement comprising adding neural cell adhesion protein to the severed nerve ends held within said implanted prosthetic device sufficient to increase the rate of growth of the nerve vis-a-vis an implant device otherwise similar except that it does not contain said neural cell adhesion protein, to regenerate the nerve, and provide greater restitution of the muscle served by the nerve.

10. The process of claim 9 wherein the implanted prosthetic device is of tubular shape, the neural cell adhesion protein is added to the tubular opening therethrough, and the proximate and distal nerve ends, respectively, are sutured to the ends thereof.

11. The process of claim 9 wherein the neural cell adhesion protein is added to said implanted prosthetic device is admixed with collagen.

12. The process of claim 11 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein:

collagen ranging from about 0.1;

1 to about 10;

1.

13. The process of claim 12 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein:

collagen ranging from about 0.4;

1 to about 1;

1.

14. The process of claim 9 wherein the neural cell adhesion protein is obtained from a human.