Tissue graft composition

• US 4,956,178 A
• Filed: 11/06/1989
• Issued: 09/11/1990
• Est. Priority Date: 07/11/1988
• Status: Expired due to Term

• Current Assignee: Methodist Hospitals of Dallas
• Original Assignee: Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Inventors: Coffey, Arthur C., Badylak, Stephen F., Lantz, Gary, Geddes, Leslie A.
• Primary Examiner(s): Stone, Jacqueline
• Assistant Examiner(s): Witz, Jean C.
• Application Number:
  US07/432,591
• Time in Patent Office: 309 Days
• Field of Search: 424/95, 623/1, 623/11, 623/12
• US Class Current: 424/551
• CPC Class Codes: A61L 27/3629 Intestinal tissue, e.g. small intestinal submucosa
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062

Abstract

This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is deliminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.

Claims

1. A tissue graft composition comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of the tunica mucosa of a segment of intestinal tissue of a warm-blooded vertebrate, said tunica submucosa, muscularis mucosa and stratum compactum being delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of said segment of intestinal tissue.

2. The tissue graft composition of claim 1 formed into a cylinder having a pre-determined luminal diameter and sutured along the length of the cylinder.

3. The tissue graft composition of claim 2 wherein the stratum compactum forms the luminal surface of the cylinder.