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Method and apparatus for determination of chemical species in body fluid

  • US 4,957,108 A
  • Filed: 09/08/1988
  • Issued: 09/18/1990
  • Est. Priority Date: 09/08/1988
  • Status: Expired due to Term
First Claim
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1. A dermal concentration patch for determining the presence of an analyte in a subject mammal'"'"'s perspiration, comprising:

  • a water permeable support layer having a first and a second side;

    at least one reagent immobilized to the support layer;

    means for removably securing the first side of the support layer in fluid communication with the subject'"'"'s skin,wherein water is permitted to escape through the support layer and outside of the concentration patch, and the reagent comprises a specific binding partner for the analyte to be determined; and

    a permeable outer protective layer disposed adjacent the second side of the support layer.

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