Steerable guidewire having electrodes for measuring vessel cross-section and blood flow

• US 4,957,110 A
• Filed: 03/17/1989
• Issued: 09/18/1990
• Est. Priority Date: 03/17/1989
• Status: Expired due to Fees

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Palermo, Thomas J., Vogel, Robert A., Berthiaume, William A.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/325,223
• Time in Patent Office: 550 Days
• Field of Search: 128/642, 128/692, 128/693, 128/772, 128/784, 128/786
• US Class Current: 600/381
• CPC Class Codes: A61B 5/027 using catheters
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/6851 Guide wires
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61B 5/6855 with a distal curved tip

Abstract

A small diameter steerable guidewire that is used to guide a catheter in transluminal coronary angioplasty is provided with a pair of electrodes for measuring the cross-sectional area of a blood vessel and for measuring blood flow. The guidewire includes a shaft and a tip attached to the distal end of the shaft. The shaft is torsionally rigid along its length and includes a conductive tube and a wire extending through the tube. The tip, which can be bent to a prescribed curve when relaxed, is sufficiently flexible to adapt to and follow the contours of a blood vessel. The tip includes a tapered extension of the wire in the shaft. A proximal electrode and a distal electrode are coaxially mounted on the tapered wire and are electrically connected to the tube and the wire, respectively. The electrodes are axially spaced apart by a predetermined distance. Each electrode is preferably a conductive, helically-wound spring. The outside diameter of the steerable guidewire preferably does not exceed about 0.020-inch for coronary use.

Claims

1. A steerable guidewire comprising:

an elongated shaft having a distal end and a proximal end, said shaft being sufficiently torsionally rigid along its length for controllably transmitting to the distal end substantially all of the rotation applied to the proximal end, said shaft including a first electrical conductor and a second electrical conductor insulated from said first electrical conductor, said electrical conductors extending from the distal end to the proximal end of said shaft; and

a tip attached to the distal end of said shaft, said tip adapted to be bent to a desired curve, said tip being sufficiently flexible so as to adapt to and follow the contours of a blood vessel, said tip including a distal electrode electrically connected to one of said conductors and a proximal electrode electrically connected to the other of said conductors, said electrodes being axially spaced apart on said tip by a predetermined distance, said distal electrode comprising a distal, conductive, helically-wound spring and said proximal electrode comprising a proximal, conductive helically-wound spring, said tip including a tapered distal region of said second conductor passing through said proximal spring at and least a portion of said distal spring and electrically connected to said distal spring.

2. A steerable guidewire as defined in claim 1 wherein said shaft and said tip have a diameter that does not exceed about 0.020-inch.

3. A steerable guidewire as defined in claim 1 wherein said first conductor comprises a main conductive tube having a lumen therethrough.

4. A steerable guidewire as defined in claim 3 wherein said second conductor comprises a wire extending through the lumen in said tube.

5. A steerable guidewire as defined in claim 1 wherein said tube includes a distal end and wherein said tapered distal region of said second conductor includes a tapered distal region of said wire extending beyond the distal end of said tube, said tapered distal region of said wire passing through said proximal spring and at least a portion of said distal spring.

6. A steerable guidewire as defined in claim 5 wherein a distal spring is electrically connected to the tapered distal region of said wire.

7. A steerable guidewire as defined in claim 6 wherein said proximal spring is electrically connected to said tube.

8. A steerable guidewire as defined in claim 7 wherein said proximal spring and said distal spring are axially spaced apart by a cylindrical insulating spacer on said wire.

9. A steerable guidewire as defined in claim 7 wherein said proximal spring, said distal spring and said spacer have approximately equal outside diameters.

10. A steerable guidewire as defined in claim 8 further including an insulating layer around said tube and said proximal electrode except for a portion of said proximal electrode adjacent to said spacer.

11. A steerable guidewire as defined in claim 10 wherein said insulating layer comprises a polyimide sleeve.

12. A steerable guidewire as defined in claim 8 wherein said spacer has an axial length of about 2 millimeters.

13. A steerable guidewire as defined in claim 6 wherein said proximal spring is spaced from the distal end of said tube and is electrically connected thereto by a conductive ribbon.

14. A steerable guidewire as defined in claim 4 wherein said wire is insulated from said tube by an insulating coating on said wire.

15. A steerable guidewire as defined in claim 4 wherein said wire is insulated from said tube by a polyimide sleeve on said wire.

16. A steerable guidewire as defined in claim 4 further including a proximal conductive tube proximally spaced from said main tube and electrically connected to said wire.

17. A steerable guidewire as defined in claim 4 wherein said tube as an outside diameter of about 0.016-inch, and said wire has an outside diameter of about 0.008-inch.

18. A steerable guidewire as defined in claim 1 wherein said distal electrode is radiopaque.

19. A steerable guidewire as defined in claim 1 wherein said electrodes are axially spaced apart by a distance that is sufficiently small to provide highly localized measurements.

20. A small diameter steerable guidewire comprising;

a main conductive tube having a proximal end and a distal end;

a conductive wire extending through said tube and having a tapered distal region extending beyond the distal end of said tube, said wire being electrically insulated from said tube;

a distal, conductive, helically-wound spring receiving at least a portion of the distal region of said wire, said distal spring constituting a distal electrode and being electrically connected to said wire;

a proximal, conductive, helically-wound spring having the distal region of said wire extending therethrough, said proximal spring constituting a proximal electrode and being electrically connected to said tube; and

means for spacing said distal and proximal electrodes by a predetermined distance on the distal region of said wire.

21. A steerable guidewire as defined in claim 20 wherein said proximal spring is connected directly to said tube.

22. A steerable guidewire as defined in claim 21 wherein said proximal spring and said distal spring are coaxial with said wire.

25. A steerable guidewire as defined in claim 20 wherein each electrode is fabricated of platinum.

26. A steerable guidewire as defined in claim 20 wherein said distal electrode is radiopaque.

27. A steerable guidewire as defined in claim 20 wherein said spacing means comprises a cylindrical insulating spacer having an outside diameter approximately equal to the outside diameters of said proximal and distal electrodes.

28. A steerable guidewire as defined in claim 20 wherein said tube, said proximal electrode and said distal electrode each have an outside diameter of about 0.020-inch or less.

29. A steerable guidewire as defined in claim 20 further including an insulating layer around said tube and said proximal electrode except for a portion of said proximal electrode adjacent to said spacing means.

30. A steerable guidewire as defined in claim 31 wherein said insulating layer comprises a polyimide tube.

31. A steerable guidewire as defined in claim 29 wherein said insulating layer comprises an insulating tube.

32. A steerable guidewire as defined in claim 20 wherein said tube is insulated from said wire by an insulating coating on said wire.

33. A steerable guidewire as defined in claim 20 wherein said tube is insulated from said wire by a polyimide sleeve on said wire.

34. A steerable guidewire as defined in claim 20 wherein said tube, said proximal electrode and said distal electrode have approximately the same outside diameters.

35. A steerable guidewire as defined in claim 20 further including a proximal conductive tube proximally spaced from said main tube and coaxial with said wire, said proximal tube being electrically connected to said wire.

36. A steerable guidewire as defined in claim 20 wherein said tube has an outside diameter of about 0.016-inch, and said wire has an outside diameter of about 0.008 inch.

37. A steerable guidewire as defined in claim 20 wherein said proximal electrode is spaced from the distal end of said tube and is electrically connected thereto by a conductive ribbon.

38. A steerable guidewire as defined in claim 37 wherein a region between the distal end of said tube and said proximal electrode is covered with a insulating tube.

39. A steerable guidewire as defined in claim 37 wherein said main conductive tube, said distal and proximal springs and said means for spacing each have an outside diameter not greater than about 0.020-inch.

40. A steerable guidewire as defined in claim 20 wherein said proximal electrode is spaced from the distal end of said tube, wherein a region between the distal end of said tube and said proximal electrode is covered with an insulating tube and wherein said proximal electrode is electrically connected to said tube.

23. A steerable guidewire as defined in claim 23 wherein the materials of said proximal electrode and said distal electrode are selected to approximately equalize the electrical resistances of the electrodes.

24. A steerable guidewire as defined in claim 23 wherein said proximal electrode is longer than said distal electrode, wherein said proximal electrode is fabricated of silver stainless steel and wherein said distal electrode is fabricated of platinum.