Diagnostic apparatus for intrinsic fluorescence of malignant tumor

• US 4,957,114 A
• Filed: 06/28/1988
• Issued: 09/18/1990
• Est. Priority Date: 04/01/1985
• Status: Expired due to Term

• Current Assignee: Jinrong Wu, Jiude Zhu, Kun Zeng, Sen Yang, Zhenfen Yu
• Original Assignee: Jinrong Wu, Jiude Zhu, Kun Zeng, Sen Yang, Zhenfen Yu
• Inventors: Yang, Sen, Wu, Jinrong, Zhu, Jiude, Zeng, Kun, Yu, Zhenfen
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/212,630
• Time in Patent Office: 812 Days
• Field of Search: 128/633, 128/634, 128/653, 128/665, 128/303.1, 128/395, 128/397, 128/398, 606/3, 606/15
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence

Abstract

This invention relates to a diagnostic apparatus and particularly to an apparatus for the diagnosis of malignant tumor and the method of using the apparatus for diagnosis. The apparatus employs an ultraviolet light source with an emitting waveband of 3000A-4000A. Light from the light source is transmitted through a bundle of quartz optic fibers to the surface of the tumor, whether benign or malignant, to stimulate it, which then generates a specific intrinsic fluorescence spectrum. The intrinsic fluorescence spectrum reflected from the surface of the tumor is transmitted by a second bundles of glass fibers placed near it to a color resolution means, then processed by a scanning means and a circuit means, and displayed recorded by a display recording means. The display may be a graphic presentation of the intrinsic fluorescence spectrum of the tumor that is tested. If the graphic presentation displayed includes a single peak within the range of the blue color band, it indicates that the tumor being tested is benign. If however, a second peak appears within the range of the red color band of the graphic presentation it is a characteristic peak of malignancy, indicating the existence of a malignant tumor. The presence of the red color can be established by eye rather than a complex color resolution system.

Claims

1. An apparatus for the diagnosis of malignant tumors comprising:

(a) means for generating near ultraviolet light having a frequency range of 3000°

A to 4000°

A;

(b) light transmission means composed of a bundle of optical fibers for transmitting the light to the surface of a tumor in order to stimulated intrinsic fluorescent light emission from said tumor;

(c) further light transmission means composed of a second bundle of optical fibers having an incident end and an efferent end for transmitting the stimulated intrinsic fluorescence light emitted by the tumor wherein the incident end of said second bundle of optical fibers has means to maintain the incident end of the fibers in a position perpendicular to the surface of the tumor;

(d) color resolution means connected to the efferent end of said second bundle of optical fibers for processing the intrinsic fluorescent light output therefrom in order to determine the presence of light of a frequency of 6000°

A to 6900°

A, characterizing the presence of a malignant tumor.

2. The apparatus of claim 1 wherein the light source means is a mercury lamp with a set of ultraviolet filters.

3. The apparatus of claim 1 wherein said light source means is an ultraviolet laser selected from the group consisting of Nitrogen laser, a Krypton laser, an Xenon laser, and an ultraviolet excimer laser.

4. The apparatus of claim 1 wherein the end of the fiber optic bundle transmitting the near-ultraviolet light that is nearest the tumor and the incident end of the fiber optic bundle transmitting the generated intrinsic fluorescent light form a 45-degree angle with respect to each other.

5. The apparatus of claim 1 wherein the ultraviolet light means provides light of 3400°

A±

200°

A.

6. The apparatus of claim 1 wherein the optical fibers for transmitting the near ultraviolet light to the surface of the tumor are made of quartz.

7. An apparatus for the visual diagnosis of malignant tumors comprising:

(a) means for generating near ultraviolet light having a frequency range of 3000°

A to 4000°

A;

(b) light transmission means composed of a bundle of optical fibers for transmitting the ultraviolet light to the surface of a tumor in order to stimulate intrinsic fluorescent light emission from said tumor;

(c) further light transmission means composed of a second bundle of optical fibers having an incident end and an efferent end for transmitting the stimulated intrinsic fluorescent light emitted by the tumor wherein the presence of red light having a frequency of 6000°

A to 6900°

A emerging from the efferent end of said second bundle of optical fibers indicates the presence of a malignant tumor.