Capillary transport zone coated with adhesive

• US 4,957,582 A
• Filed: 03/16/1989
• Issued: 09/18/1990
• Est. Priority Date: 03/16/1989
• Status: Expired due to Fees

• Current Assignee: Clinical Diagnostic Systems Inc.
• Original Assignee: Eastman Kodak Company
• Inventors: Columbus, Richard L.
• Primary Examiner(s): Gallagher, John J.
• Application Number:
  US07/324,140
• Time in Patent Office: 551 Days
• Field of Search: 156/278, 156/332, 156/292, 422/100, 436/180, 128/760, 73/864.91, 73/53, 204/403, 204/416
• US Class Current: 156/332
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2300/161 Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
• CPC Class Codes: B01L 2300/163 Biocompatibility
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A device for liquid transport, and a method of making it, are described. The device features a capillary transport zone comprising opposing sufaces formed from supporting material having unsatisfactory wettability. The wettability is improved by applying a coating of an adhesive.

Claims

1. In a device providing a liquid transport zone for moving liquid along a path by capillary action, said zone comprising opposing surfaces joined together so as to provide a capillary spacing between said surfaces, said surfaces comprising a supporting material having an equilibrium contact angle with serum that is greater than about 80°

or less than about 30°

,

the improvement wherein at least one of said opposing surfaces is coated in at least a portion of said transport zone with an adhesive capable of bonding together said supporting material of said surfaces, said adhesive, when cured, having an equilibrium contact angle with serum that is less than about 80° and

greater than about 30°

.

2. A device as defined in claim 1, wherein said adhesive is also disposed between said supporting material of said surfaces where they are joined together.

3. A device as defined in claim 1, wherein said cured adhesive provides an equilibrium contact angle with serum that is between about 65°

and about 75°

.

4. A device as defined in claim 1 or 2, wherein said adhesive comprises an amorphous polyester comprising a glycol and terephthalic acid, having from about 30 to about 50 mole percent of its recurring glycol units being derived from diethylene glycol, and from about 50 to about 70 mole percent of its recurring glycol units being derived from ethylene glycol.

5. A device as defined in claim 4, wherein said adhesive is poly(ethylene-co-2,2'"'"'-oxydiethylene terephthalate).

6. A device as defined in claim 1 or 2, wherein said adhesive is selected from the group consisting of poly(ethylene-co-2,2'"'"'-oxydiethylene terephthalate), and poly(2,2-dimethyl-1,3-propylene-co-2,2'"'"'-oxydiethylene terephthalate).

7. A method of making a device containing a liquid transport zone capable of transporting a patient sample through the zone via capillary action, said zone comprising opposing surfaces joined together so as to provide a capillary spacing between said surfaces, said surfaces comprising a supporting material having an equilibrium contact angle with serum that is outside the range of about 30°

to about 80°

,

the method comprising the steps of

(a) providing said supporting material configured with said opposing surfaces;

(b) coating at least a portion of said supporting material of at least one of said surfaces with an adhesive capable of bonding together said supporting material of said surfaces, said adhesive, when cured, having an equilibrium contact angle with serum that is less than about 80° and

greater than about 30°

, some of the adhesive being applied in at least a portion of the area of said transport zone;

(c) joining said supporting materials; and

(d) curing said adhesive.

8. A method as defined in claim 7, and further including the step of applying said adhesive to said supporting material of one of said surfaces at locations designed to contact said supporting material of the other of said surfaces,

so that in step (c), said supporting materials are joined together by said adhesive disposed between them.

9. A method as defined in claim 8, wherein said adhesive is applied to said opposing surface and to said contacting locations in a single pass.

10. A method as defined in claim 7 or 8, wherein said adhesive comprises an amorphous polyester of a glycol and terephthalic acid, having from about 30 to about 50 mole percent of its recurring glycol units being derived from diethylene glycol, and from about 50 to about 70 mole percent of its recurring glycol units being derived from ethylene glycol.

11. A method as defined in claim 10, wherein said adhesive is poly(ethylene-co-2,2'"'"'-oxydiethylene terephthalate).

12. A method as defined in claim 7, wherein said adhesive is selected from the group consisting of poly(ethylene-co-2,2'"'"'-oxydiethylene terephthalate), and poly(2,2-dimethyl-1,3-propylene-co-2,2'"'"'-oxydiethylene terephthalate).