Preparation of pharmaceutical mixtures

• US 4,957,681 A
• Filed: 04/03/1989
• Issued: 09/18/1990
• Est. Priority Date: 04/15/1988
• Status: Expired due to Term

• Current Assignee: BASF AG (BASF SE)
• Original Assignee: BASF AG (BASF SE)
• Inventors: Klimesch, Roger, Schlemmer, Lothar, Bleckmann, Gerhard
• Primary Examiner(s): Thurlow, Jeffery
• Assistant Examiner(s): Tentoni, Leo B.
• Application Number:
  US07/331,959
• Time in Patent Office: 533 Days
• Field of Search: 264/176.1, 264/211.23, 264/328.1, 264/122, 222/1, 222/77
• US Class Current: 264/211.23
• CPC Class Codes: A61K 9/2095 Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: B29C 45/0001 characterised by the choice of material
• CPC Class Codes: B29K 2105/0035 Medical or pharmaceutical agents

Abstract

Pharmaceutical mixtures are prepared by continuous metering of the components and shaping by a conventional method.

Claims

1. A continuous process for the preparation of a pharmaceutical mixture having at least two components, wherein the components of the mixture are continously metered which comprises:

(a) continuously metering the individual components of the pharmaceutical mixture at a rate of at least 50 g/h on electronic differential metering balances having a metering accuracy of at least ±

5% within time intervals less than 1 minute and having screw conveyors, thereby obtaining a substantially uniformly metered mixture, and

(b) shaping said mixture.

2. The continuous process as claimed in claim 1, wherein said electronic differential metering balances having screw conveyors comprise intermeshing, self-purging twin screws as a conveying element.

3. The continuous process as claimed in claim 1, wherein said mixture containing said metered components is shaped into tablets.