Method for delivering somatotropin to an animal

• US 4,959,218 A
• Filed: 12/28/1988
• Issued: 09/25/1990
• Est. Priority Date: 03/25/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Judy A., Eckenhoff, James B., Wright, Jeremy C., Peery, John R., Cortese, Richard
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Horne, Leon R.
• Application Number:
  US07/291,930
• Time in Patent Office: 636 Days
• Field of Search: 424/473, 424/422, 424/423
• US Class Current: 424/473
• CPC Class Codes: A61K 38/27 Growth hormone [GH], i.e. somatotropin
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the device and means in the space for shielding the beneficial agent from fluid.

Claims

1. A method for delivering a somatotropin to an animal comprising an aqueous-biological fluid, wherein the method comprises:

(a) admitting into the animal a delivery device comprising;

(1) a wall;

(2) an internal space defined by the wall;

(3) a somatotropin protected from the aqueous-biological fluid in the internal space;

(4) exit means for connecting the exterior and the interior of the device;

(5) means in the space for occupying the space occupied by the somatotropin; and

,

(b) delivering the somatotropin by the means occupying space and thereby displacing the somatotropin through the exit means to the animal.

2. A method of redelivering a somatotropin to livestock comprising a biological fluid, wherein the method comprises:

(a) admitting into livestock a delivery deivce comprising;

(1) means for storing a beneficial composition during its residency in the device;

(2) a beneficial composition comprising a somatotropin and a pharmaceutically acceptable carrier shielded from the fluid in the means;

(3) means in the device for pushing the beneificial composition from the device;

(4) at least one passageway connecting the exterior and the interior of the device; and

,

(b) delivering the somatotropin by the means pushing the beneficial composition through the passageway to the livestock over time.