Dermal substance collection device

• US 4,960,467 A
• Filed: 12/12/1988
• Issued: 10/02/1990
• Est. Priority Date: 02/11/1985
• Status: Expired due to Fees

• Current Assignee: The United States Of America As Represented By The Secretary Of The Army
• Original Assignee: The United States Of America As Represented By The Secretary Of The Army
• Inventors: Peck, Carl C.
• Primary Examiner(s): Dixon, Jr., William R.
• Assistant Examiner(s): Brunsman, David M.
• Application Number:
  US07/283,347
• Time in Patent Office: 659 Days
• Field of Search: 252/408.1, 252/194, 106/209, 128/632, 502/404
• US Class Current: 252/408.1
• CPC Class Codes: A61B 10/0064 for taking sweat or sebum samples measuring sweat production A61B5/4266
• CPC Class Codes: A61B 2010/0009 Testing for drug or alcohol abuse
• CPC Class Codes: G01N 33/48 Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02

Abstract

A dermal substance collection device (DSCD) is described which provides ms for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.

Claims

1. A gelled composition for the collection of a chemical substance from a dermal surface, said gelled composition consisting essentially of:

(a) A binding reservoir material, having a particle size in the colloid range, for binding with said dermal substance to prevent back transfer loss of said dermal substance from said binding reservoir to the dermal surface; and

(b) A liquid bridge transfer medium which comprises an aqueous gel that allows the instantaneous and continuous transfer of said dermal substance from the dermal surface to said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium.

2. A composition according to claim 1 wherein said binding reservoir material is dispersed in said liquid bridge transfer medium.

3. A composition according to claim 2 wherein said binding reservoir material is activated charcoal.

4. A composition according to claim 1 wherein said aqueous gel includes an osmotically active substance.

5. A composition according to claim 1 wherein said aqueous gel comprises an agarose gelling agent.

6. A composition according to claim 1 wherein said aqueous gel comprises a polyvinyl alcohol polymer gelling agent.

7. A composition according to claim 1 wherein said aqueous gel includes a penetration enhancing agent.

8. A composition according to claim 7 wherein the penetration enhancing agent is selected from the group consisting of n,n-diethyl-m-toluamide, 1-dodecylazacycloheptan-2-one, and dimethyl sulfoxide.

9. A composition according to claim 4 wherein said aqueous gel consists essentially of an osmotically active aqueous solution and an agarose gelling agent.

10. A composition according to claim 9 wherein said osmotically active aqueous solution contains sodium chloride present in an amount up to saturation of said aqueous gel.

11. A composition according to claim 10 wherein the amount of agarose is 0.5 to 30% by weight of the aqueous sodium chloride solution and the amount of activated charcoal is 0.5 to 30% by weight of the aqueous gel.

12. A composition according to claim 11 wherein the amount of agarose is about 3 weight-percent of the sodium chloride solution and the amount of activated charcoal is about 5 weight-percent of the aqueous gel.

13. A composition according to claim 1 wherein said binding reservoir is selected from the group consisting of activated charcoal, ion-exchange resin, immobilized antibody, silica, zeolite and molecular sieve.