Method and apparatus for volumetric interstitial conductive hyperthermia

• US 4,961,422 A
• Filed: 05/02/1988
• Issued: 10/09/1990
• Est. Priority Date: 01/21/1983
• Status: Expired due to Term

• Current Assignee: MED Institute, Inc. (Cook Group Incorporated)
• Original Assignee: Christopher J. Moran, Marchosky J. Alexander, Neal E. Fearnot
• Inventors: Moran, Christopher J., Fearnot, Neal E., Marchosky, J. Alexander
• Primary Examiner(s): Coven, Edward M.
• Assistant Examiner(s): Harrison, Jessica
• Application Number:
  US07/193,167
• Time in Patent Office: 890 Days
• Field of Search: 128/399, 128/400, 128/401, 128/402, 128/303 B, 128/303.1, 128/303.12, 128/303.18, 128/303.19, 128/736, 128/742, 128/784, 128/804
• US Class Current: 607/99
• CPC Class Codes: A61B 2017/00022 Sensing or detecting at the treatment site
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61F 2007/0093 programmed
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/00 Heating or cooling appliances for medical or therapeutic treatment of the human body heating or cooling means in connection with bedsteads or mattresses A47C21/00 ; massage, therapeutic baths A61H; hyperthermia using electric or magnetic fields or ultrasound A61N; electric heating elements H05B
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 2005/1012 Templates or grids for guiding the introduction of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy
• CPC Class Codes: H02J 2310/23 The load being a medical device, a medical implant, or a life supporting device
• CPC Class Codes: H02J 50/10 using inductive coupling
• CPC Class Codes: H02J 7/0048 Detection of remaining charge capacity or state of charge [SOC]

Abstract

A system and method for producing volumetric conductive hyperthermia for the treatment of a cancerous tumor in a patient. The location and volume of the tumor are determined with the aid of a CT scanning system, and an array of probes each containing a heat-emitting element is formed by interstitial implantation in the tumor in a predetermined pattern for volumetric heating using a template for guiding the probes into parallel alignment in the tumor. The template is affixed with respect to the patient'"'"'s body and with respect to the imaging plane of the CT scanning system. After implantation, the probes are connected to a manifold connector which is in turn connected to an external control system capable of independently controlling the probes while monitoring various analog and digital values representative of system performance.

Claims

1. A method of producing volumetric, thermally conductive hyperthermia for the treatment of a cancerous tumor in a patient, comprising the steps:

determining the location and volume of the tumor with an imaging system;

interstitially implanting a plurality of heat-emitting sources in the tumor in a predetermined pattern for volumetric, thermally conductive heating of said tumor; and

controllably energizing said heat-emitting sources to produce volumetric, thermally conductive heating of said tumor and a predetermined temperature distribution in said tumor.

2. The method of claim 1 wherein said implanting step includes guiding said heat-emitting sources into position in the tumor with the aid of said imaging system.

3. The method of claim 2 wherein said implanting step further includes drilling individual holes for placement of respective individual probes each carrying at least one of said heat emitting sources, said probes each having a flexible proximal end protruding from the patient'"'"'s body after said implanting step is performed;

and wherein said energizing step includes supplying electrical energy from an external control system to said heat-emitting sources through said proximal ends of said probes;

said method further comprising the step;

securing said proximal ends of said probes to the patient'"'"'s body.

4. The method of claim 3 wherein said energizing step is performed according to a predetermined treatment protocol including multiple hyperthermia intervals separated by intervals of normothermia.

5. The method of claim 4 further comprising the step:

measuring the temperature of at least one of said heat-emitting sources;

wherein said energizing step is performed with a closed-loop control system responsive to the temperature measured in said measuring step.

6. The method of claim 1 wherein said implanting step further includes drilling individual holes for placement of respective individual probes each carrying at least one of said heat-emitting sources, said probes each having a flexible proximal end protruding from the patient'"'"'s body after said implanting step is performed;

and wherein said energizing step includes supplying electrical energy from an external control system to said heat-emitting sources through said proximal ends of said probes;

said method further comprising the step;

securing said proximal ends of said probes to the patient'"'"'s body.

7. The method of claim 1 wherein said energizing step is performed according to a predetermined treatment protocol including multiple hyperthermia intervals separated by intervals of normothermia.

8. The method of claim 1 further comprising the step:

measuring the temperature of at least one of said heat-emitting sources;

wherein said energizing step is performed with a closed-loop control system responsive to the temperature measured in said measuring step.

9. A system for producing volumetric, thermally conductive hyperthermia for the treatment of a cancerous tumor in a patient, comprising:

imaging means for determining the location and volume of the tumor, said imaging means including means for establishing an imaging plane through the patient'"'"'s body;

a heat-emitting source including a plurality of implantable probes each containing a heat-emitting element;

means for interstitially implanting said probes in the tumor in a predetermined pattern for volumetric, thermally conductive heating of said tumor, said implanting means including template means for guiding said probes into parallel alignment in the tumor, and means for affixing said template means with respect to the patient'"'"'s body and with respect to said imaging plane; and

means for controllably energizing said heat-emitting sources to produce volumetric, thermally conductive heating of the tumor and a predetermined temperature distribution in the tumor.

10. The system of claim 9 wherein said template means includes a radiolucent template block, said template block defining a plurality of parallel holes each corresponding with a respective one of said probes.

11. The system of claim 10 wherein said probes each include a flexible proximal end having a plurality of electrical terminals, and wherein said energizing means includes an external control system, manifold connector means for mechanically terminating said proximal ends of said probes and electrically connecting said external control system to said electrical terminals, and means for detaching said manifold connector means from said external control system.

12. The system of claim 11 further comprising means for measuring temperature within the tumor,

wherein said control system includes closed-loop control means responsive to the measured temperature for maintaining a selected minimum temperature condition in the tumor.

13. The system of claim 12 wherein said control system includes means for selecting a predetermined time duration for maintaining said heat-emitting element energized to maintain said selected minimum temperature condition in the tumor.

14. The system of claim 13 wherein said control system includes means for establishing a predetermined frequency of treatment cycles when said heat-emitting element is energized.

15. The system of claim 14 wherein said heat-emitting elements are resistive heater elements and said controlled energy is electrical current.

16. A method of treating tumors with volumetric, thermally conductive hyperthermia, comprising the steps:

surgically inserting a plurality of heat-emitting elements and temperature sensors into a tumor with the aid of an imaging system;

energizing said heat-emitting elements with an electrical current to produce volumetric, thermally conductive heating of said tumor;

measuring the temperature of said heat-emitting elements with said temperature sensors; and

automatically controlling the application of electrical energy to said heat-emitting elements according to the difference between the measured temperature and a predetermined temperature selected for each of said heat-emitting elements to produce a predetermined temperature distribution in said tumor.