Controlled release of macromolecular polypeptides
First Claim
Patent Images
1. A composition for the controlled administration of a biologically active macromolecular polypeptide comprising (a) a polylactide matrix in which is incorporated a micro-suspension of not more than about 30 percent by weight based on weight of the system of (b) particles of at least one biologically active macromolecular polypeptide having a molecular weight not less than about 1000 daltons, wherein substantially all of the particles of polypeptide have a diameter of 10μ
- or less and are uniformly and discreetly dispersed throughout the matrix, and wherein the polypeptide retains at least about 50 percent of the biological activity which it possessed prior to manufacture of the composition.
1 Assignment
0 Petitions
Accused Products
Abstract
An active agent delivery system for the controlled administration of macromolecular polypeptides which comprises a micro-suspension of water-soluble components in a polylactide matrix.
327 Citations
42 Claims
-
1. A composition for the controlled administration of a biologically active macromolecular polypeptide comprising (a) a polylactide matrix in which is incorporated a micro-suspension of not more than about 30 percent by weight based on weight of the system of (b) particles of at least one biologically active macromolecular polypeptide having a molecular weight not less than about 1000 daltons, wherein substantially all of the particles of polypeptide have a diameter of 10μ
- or less and are uniformly and discreetly dispersed throughout the matrix, and wherein the polypeptide retains at least about 50 percent of the biological activity which it possessed prior to manufacture of the composition.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
Specification