Porous ceramic material and processes for preparing same

• US 4,963,145 A
• Filed: 03/20/1989
• Issued: 10/16/1990
• Est. Priority Date: 07/09/1983
• Status: Expired due to Fees

• Current Assignee: Sumitomo Chemical Company Limited
• Original Assignee: Sumitomo Chemical Company Limited
• Inventors: Yamauchi, Shigeru, Takagi, Shigehide
• Primary Examiner(s): Hafer, Robert A.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/325,098
• Time in Patent Office: 575 Days
• Field of Search: 128/92 YG, 128/924 YQ, 128/92 YR, 501/80, 606/76
• US Class Current: 606/76
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C04B 2111/00836 for medical or dental applications
• CPC Class Codes: C04B 2111/00844 for electronic applications
• CPC Class Codes: C04B 33/24 Manufacture of porcelain or white ware
• CPC Class Codes: C04B 38/0051 characterised by the pore size, pore shape or kind of porosity
• CPC Class Codes: C04B 38/065 characterised by physical aspects, e.g. shape, size or porosity
• CPC Class Codes: C04B 38/067 Macromolecular compounds C04B38/062 takes precedence; polysaccharides C04B38/0645
• CPC Class Codes: C04B 38/106 by adding preformed foams

Abstract

A porous ceramic material composed of a sintered porous body of a calcium phosphate compound is described. A multiplicity of capillary void paths having a diameter of 1 to 30 μm and a multiplicity of pores having a diameter of 1 to 600 μm are formed in the sintered porous body. At least part of the pores are connected to the exterior space of the sintered porous body through at least a part of the capillary voids. The porous ceramic material is valuable as a medical material, e.g., a substitute or prosthesis for bone or dental root, and also an electronic material and a genetic engineering material.

When the porous ceramic material is embedded in a bone defect of human or animals, osteolytic cells, osteoblasts, erythrocytes and body fluid are selectively allowed to intrude through the porous ceramic material while almost no intrusion of osteoclasts and collagen fibers is allowed. Accordingly, the porous ceramic material can be utilized for inducing new-born bone, controlling resorption of bone with age, remedying bone defects.

Claims

1. A porous ceramic material comprising a sintered porous body of a calcium phosphate compound, wherein a multiplicity of capillary void paths having a diameter in the range of 1 to 30 μ

m and a multiplicity of pores interconnected by said capillary void paths having a diameter of 3 to 600 μ

m are formed in the sintered porous body and at least part of said pores are connected to the exterior space of the sintered porous body through at least a part of said capillary void paths and wherein all of the capillary void paths have substantially the same diameters and said pores are substantially spherical, and the diameters of said capillary void paths are smaller than the diameters of said pores.

2. A ceramic material according to claim 1, wherein the atomic ratio of calcium to phosphorus in the calcium phosphate compound is in the range of from 1.30 to 1.80.

3. A ceramic material according to claim 1, wherein the calcium phosphate compound is hydroxyapatite.

4. A ceramic material according to claim 1, wherein the size of said pores is in the range of from 3 to 300 microns.

5. A ceramic material according to claim 1, wherein the diameter of the capillary void paths is in the range of from 1 to 20 microns.

6. A ceramic material according to claim 1, wherein the porous body has a porosity of 40 to 90%.

13. A ceramic material according to claim 1 wherein the diameter of said pores is in the range of from 3 to 300 microns and the diameter of the capillary void paths is in the range of from 1 to 20 microns.

14. A ceramic material according to claim 1 wherein the pores have diameters in the range of from more than 12 to 500 μ

m and the capillary void paths have a diameter of about 12 μ

m.

15. A ceramic material according to claim 1 which is comprised of a multiplicity of capillary void paths having a diameter of from 5 to 10 μ

m and a multiplicity of pores interconnected by the capillary void paths, said pores having diameters in the range of from more than 10 to 500 μ

m.

16. A ceramic material according to claim 1 which comprises a multiplicity of capillary void paths having a diameter of from 1 to 30 μ

m and a multiplicity of pores interconnected by said capillary void paths, said pores having a diameter in the range of from 100 to 500 μ

m.

18. A ceramic material according to claim 1 which comprises capillary void paths having a diameter in the range of from 2 to 10 μ

m and a multiplicity of pores interconnected by said capillary void paths, said pores having a diameter of from 30 to 300 μ

m.

19. A ceramic material according to claim 1 wherein said pores are spherical.

7. A method for inducing a newborn bone which comprises filling or embedding in a defect of a bone of a human or animal, a porous ceramic material composed of a sintered porous body of a calcium phosphate compound, wherein a multiplicity of capillary void paths having a diameter of 1 to 30 μ

m and a multiplicity of pores interconnecting by said capillary void paths and having a diameter of 3 to 600 μ

m are formed in the sintered porous body and at least part of said pores are connected to the exterior space of the sintered porous body through at least a part of said capillary void paths, said capillary void paths having substantially the same diameters, said pores being substantially spherical and the diameters of said capillary void paths being smaller than the diameters of said pores, whereby a new-born bone is induced while intrusion of collagen fibers and osteoclasts into the porous ceramic material is restricted.

8. A method according to claim 7, wherein the atomic ratio of calcium to phosphorus in the calcium phosphate compound is in the range of from 1.30 to 1.80.

9. A method according to claim 7, wherein the calcium phosphate compound is hydroxyapatite.

10. A method according to claim 7, wherein the diameter of said pores is in the range of from 3 to 300 microns.

11. A method according to claim 7, wherein the diameter of the capillary void paths is in the range of from 1 to 20 microns.

12. A method according to claim 7, wherein the porous body has a porosity of 40 to 90%.

17. A ceramic material according to claim 7 wherein the capillary void paths have a diameter in the range of from about 5 to 10 μ

m.