Hollow fiber membrane fluid processor

• US 4,966,699 A
• Filed: 04/10/1989
• Issued: 10/30/1990
• Est. Priority Date: 05/25/1988
• Status: Expired due to Term

• Current Assignee: Asahi Kasei Kuraray Medical Company Limited (Asahi Kasei Corporation)
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: Matsumoto, Yutaka, Sasaki, Masatomi, Morita, Hirotomo
• Primary Examiner(s): SPEAR JR, FRANK
• Application Number:
  US07/335,543
• Time in Patent Office: 568 Days
• Field of Search: 210/321.8, 210/500.29, 210/500.30, 210/500.31, 210/450, 210/500.23
• US Class Current: 210/321.8
• CPC Class Codes: B01D 63/02 Hollow fibre modules
• CPC Class Codes: B01D 63/021 Manufacturing thereof
• CPC Class Codes: B01D 63/0233 forming the bundle
• CPC Class Codes: B01D 63/033 Specific distribution of fibres within one potting or tube-sheet
• CPC Class Codes: B01D 65/022 Membrane sterilisation
• CPC Class Codes: B01D 67/0088 Physical treatment with compounds, e.g. swelling, coating or impregnation
• CPC Class Codes: B01D 67/0093 Chemical modification
• CPC Class Codes: B01D 67/00931 by introduction of specific groups after membrane formation, e.g. by grafting
• CPC Class Codes: B01D 69/08 Hollow fibre membranes manufacture of hollow fibres D01D5/24, D01F1/08

Abstract

A hollow fiber membrane fluid processing apparatus comprising a housing, a fluid processing hollow fiber membrane bundle in the housing, partitions fluid tightly securing the opposed ends of the fiber bundle to the housing ends, a space being defined by the hollow fiber membrane outer surface, the housing inner surface, and the partitions, inlet and outlet ports for a first fluid disposed in the housing adjacent the opposed ends thereof in fluid communication with the space, and inlet and outlet ports for a second fluid disposed at the housing ends in fluid communication with the interior of the hollow fiber membranes is characterized in that the portion of the hollow fiber membranes in contact with each partition swells little upon contact with water-containing fluid. When contacted with physiological saline for priming and the second fluid for processing, the partition-contacting portion of the hollow fiber membranes does not absorb substantial water or expand in wall thickness, that is, maintains the inner diameter unchanged, avoiding any deleterious effect on second fluid flow and an increase of pressure loss.

Claims

1. A hollow fiber membrane blood processing apparatus comprising

a housing having opposed open ends,

a fiber bundle received in said housing and including a plurality of hollow fiber membranes for processing fluid,

partitions fluid tightly securing the opposed ends of the fiber bundle to the corresponding ends of said housing, a space being defined by the outer surface of said hollow fiber membranes, the inner surface of said housing, and the partitions,

an inlet and an outlet for a blood processing fluid disposed in said housing adjacent the opposed ends thereof in fluid communication with the space, and

an inlet and an outlet for blood disposed at the opposed ends of said housing in fluid communication with the interior of the hollow fiber membranes,

characterized in that only the portion of said hollow fiber membranes in the vicinity of where the members are in contact with each of said partitions has been treated with a reagent having a reactive group capable of reaction with a polar group that the hollow fiber membranes possess or a material contained in the hollow fiber membranes possesses.

2. The apparatus of claim 1 wherein the hollow fiber membranes are adapted for dialysis.

3. The apparatus of claim 1 wherein the polar group that the hollow fiber membranes posses or a material contained in the hollow fiber membranes possesses is a hydroxyl, amino or carboxyl group.

4. The apparatus of claim 1 wherein the reactive group is an isocyanate, epoxy, thiocyanate, acid chloride or aldehyde group.

5. The apparatus of claim 1 wherein the reagent is selected from the group consisting of diphenylmethane diisocyanate, 2,4-tolylene diisocyanate, carbodiimide modified diphenylmethane diisocyanate, hexamethylene diisocyanate, epichlorohydrin, and 1,4-butanediol diglycidyl ether.

6. A hollow fiber membrane blood processing apparatus

a housing having opposed open ends,

a fiber bundle received in said housing and including a plurality of hollow fiber membranes for processing fluid,

partitions fluid tightly securing the opposed ends of the fiber bundle to the corresponding ends of said housing, a space being defined by the outer surface of said hollow fiber membranes, the inner surface of said housing, and the partitions,

an inlet and an outlet for a blood processing fluid disposed in said housing adjacent the opposed ends thereof in fluid communication with the space, and

an inlet and an outlet for blood disposed at the opposed ends of said housing in fluid communication with the interior of the hollow fiber membranes,

characterized in that only the portion of said hollow fiber membranes in the vicinity of where the membranes are in contact with each of said partitions has a hydrophobic material coated thereon or incorporated therein.

7. The apparatus of claim 6 wherein the hollow fiber membranes are adapted for dialysis.

8. The apparatus of claim 7 wherein the hollow fiber membranes are hydrophilic hollow fiber membranes adapted for dialysis.

9. The apparatus of claim 6 wherein the partitions are coated on their outside surface with a hydrophobic material.

10. The apparatus of claim 9 wherein the hydrophobic material is silicone, urethane or fluoride resin.