Ruminant dispensing device comprising agent displacement member

• US 4,966,767 A
• Filed: 03/23/1989
• Issued: 10/30/1990
• Est. Priority Date: 08/16/1985
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B.
• Primary Examiner(s): Cashion, Jr. Merrell C.
• Assistant Examiner(s): HORNE, LEON
• Application Number:
  US07/327,935
• Time in Patent Office: 586 Days
• Field of Search: 424/438, 424/473, 604/892.1
• US Class Current: 424/438
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comrising a beneficial agent and a non-toxic heat responsive carrier in the space, and (4) a passageway in the housing for delivering the beneficial agent from the dispensing device.

Claims

1. A delivery system comprising:

(a) a wall surrounding and defining an internal compartment, the wall comprising a composition permeable to the passage of fluid that enters the delivery system;

(b) a beneficial agent in the compartment, said beneficial agent being a member selected from the group consisting of antibloat, anthelmintics, antibiotic, anti-infectious, antiparasitic, antimicrobial, and antiflea beneficial agents;

(c) exit means in the wall for connecting the internal compartment with the exterior of the delivery system for delivering the beneficial agent from the delivery system;

(d) means in the compartment for urging the beneficial agent through the exit means for delivering the beneficial agent over time; and

,

(e) a density member having a specific gravity of 2.2 to 7.6 and selected from the group consisting of iron, steel, iron-magnesium alloy, a mixture of cobalt and iron, copper oxide, iron oxide, and a mixture of copper oxide and iron comprising a specific gravity greater than the specific gravity of fluid that enters the delivery system blended in the means that urges the beneficial agent from the delivery system.

2. A delivery system according to claim 1, wherein the beneficial agent is mixed with a member selected from the group consisting of a glyceride having a melting point of at least 31°

C., and a block copolymer of 1,2-butylene oxide and ethylene oxide.

3. A delivery system according to claim 1, wherein the means for urging the beneficial agent from the delivery system is a member selected from the group consisting of poly(ethylene oxide), poly(acrylamide), poly(acrylic acid), and poly(hydroxyalkyl acrylate).

4. A delivery system according to claim 1, wherein the means for urging the beneficial agent from the delivery system is a hydrogel.

5. A delivery system according to claim 1, wherein the means for urging the beneficial agent through the exit in the wall is a composition comprising a hydrogel and an osmotically effective solute that exhibits an osmotic pressure gradient across the wall.

6. A delivery system according to claim 1, wherein the means for urging the beneficial agent through the exit means in the wall comprises a hydrogel and a member selected from the group consisting of iron, steel, iron magnesium alloy, a mixture of cobalt and iron, copper oxide, iron oxide, and a mixture of copper oxide and iron.

7. A delivery system for delivering a beneficial agent according to claim 1, wherein the means for urging the beneficial agent through the exit means in the wall comprises a hydrogel, an osmotically effective compound that exhibits an osmotic pressure gradient across the wall, and a density producing member selected from the group consisting of iron, steel, iron magnesium alloy, a mixture of cobalt and iron, copper oxide, iron oxide, and a mixture of copper oxide and iron.

8. A delivery system according to claim 1, wherein the beneficial agent is replaced by a member selected from the group consisting of a nutrient, feed additive, vitamin, and drug.

9. A delivery system according to claim 1, wherein the beneficial agent is a member selected from the group consisting of albendazole, avermectin, cambendazole, fenbendazole, ivermectin, levamisole, morantel, mebendazole, oxybendazole, oxfendazole, parbendazole, parziquantel, thiabendazole, and techloroform.