Method and apparatus for anticipating side effects manifested in a patient during dialysis treatment

• US 4,967,754 A
• Filed: 06/12/1989
• Issued: 11/06/1990
• Est. Priority Date: 06/15/1988
• Status: Expired due to Term

• Current Assignee: Gambro Hospal Schweiz AG
• Original Assignee: Hospal AG
• Inventors: Rossi, Marco
• Primary Examiner(s): Hindenburg, Max
• Application Number:
  US07/364,292
• Time in Patent Office: 512 Days
• Field of Search: 128/668, 128/670-671, 128/630, 128/389, 128/700, 604/4-6, 604/29
• US Class Current: 600/483
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/06 Heartbeat rate only
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/778 silicon

Abstract

An apparatus and method for anticipating side effects which are manifested in a patient during a dialysis treatment, respectively comprising a device and step for measuring at least one haemodynamic value of the patient a predetermined number of times to obtain a parameter corresponding to the variation of the haemodynamic value with respect to time, a device and step for calculating a rating corresponding to a mean variation of the parameter with reference to a predetermined period, a device and step for comparing the value of the rating with a reference value delimiting a range of safety values, and a device and step for emitting an alarm signal each time the value of the rating falls outside the range of safety values delimited by the reference value.

Claims

1. A method for anticipating side effects capable of manifesting themselves in a patient during a dialysis treatment, comprising the steps of:

measuring at least one haemodynamic value of the patient a predetermined number of times to establish a general trend with respect to time of said at least one haemodynamic value;

calculating, using linear regression analysis, at least one rating corresponding to the slope of a line segment following said general trend;

comparing said at least one rating with at least one reference value delimiting a range of predetermined safety values; and

emitting an alarm signal each time said at least one rating falls outside of said range of safety values.

2. A method according to claim 1, wherein said at least one measured haemodynamic value is chosen from the group consisting of the following values:

cardiac rate, electrocardiograph signal, and cardiac amplitude.

3. A method according to claim 1, further comprising the step of regulating dialysis treatment in response to an alarm signal emission.

4. An apparatus for anticipating side effects which are manifested in a patient during a dialysis treatment, comprising:

means for measuring at least one haemodynamic value of the patient a predetermined number of times to establish a general trend with respect to time of said at least one haemodynamic value;

means for calculating, using linear regression analysis, at least one rating corresponding to the slope of a line segment following said general trend;

means for comparing the value of said at least one rating with at least one reference value delimiting a range of safety values; and

means for emitting an alarm signal each time the value of said rating falls outside the range of safety values delimited by said at least one reference value.

5. An apparatus according to claim 4, wherein the measurement means measures a haemodynamic value chosen from the group consisting of the following:

cardiac rate, electrocardiograph signals, and cardiac amplitude.

6. An apparatus according to claim 4, wherein said calculating means includes a filter disposed down-line from said measurement means.

7. An apparatus as set forth in claim 4, wherein said calculating means includes memory means for storing said predetermined number of haemodynamic values supplied by said measurement means, and rating means for calculating said rating.

8. An apparatus as set forth in claim 4, wherein said calculating means further comprises a microprocessor.

9. An apparatus as set forth in claim 4, wherein said comparison means comprises at least one threshold comparator.

10. An apparatus as set forth in claim 9, wherein said comparison means further comprises at least one element for regulating a threshold reference value of the threshold comparator.

11. An apparatus as set forth in claim 4, wherein said means emits an acoustic signal.

12. An apparatus as set forth in claim 4, wherein said means emits an optical signal.

13. An apparatus as set forth in claim 4, further comprising means for controlling a dialysis machine in response to said emission of said alarm signal.