Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof

• US 4,968,350 A
• Filed: 12/09/1988
• Issued: 11/06/1990
• Est. Priority Date: 04/16/1987
• Status: Expired due to Fees

• Current Assignee: Christian Bindschaedler, Eric Doelker, Robert Gurney
• Original Assignee: Christian Bindschaedler, Eric Doelker, Robert Gurney
• Inventors: Gurny, Robert, Doelker, Eric, Bindschaedler, Christian
• Primary Examiner(s): Dixon, Jr., William R.
• Assistant Examiner(s): Bonner, Melissa
• Application Number:
  US07/294,516
• Time in Patent Office: 697 Days
• Field of Search: 106/170, 106/198, 523/223, 523/300, 523/334, 523/304, 523/309
• US Class Current: 106/163.01
• CPC Class Codes: A61K 9/286 Polysaccharides, e.g. gums; Cyclodextrin
• CPC Class Codes: B01J 13/12 removing solvent from the wall-forming material solution
• CPC Class Codes: C08J 3/07 from polymer solutions
• CPC Class Codes: C08J 3/14 by precipitation from solutions C08J3/122 takes precedence

Abstract

The process for preparing a redispersible powder of a water-insoluble polymer by a producing a gel of a water-soluble macromolecular substance and water. Then a second solution is prepared by mixing a single organic solvent which is partially miscible with water and a water-insoluble polymer. These two solutions are emulsified and then water is added to diffuse the solvent to form microparticles in suspension. The particles are collected by a conventional method.

Claims

1. A process for preparing a powder of water-insoluable polymer which can be redispersed in a liquid phase, comprising the steps of:

(a) preparing a concentrated aqueous solution of a solute to which is added a water-soluble macro-molecular substance in a quantity sufficient to produce a viscous solution or a gel;

(b) separately preparing a second solution of water-insoluable polymer, said polymer selected from the group consisting of cellulose and cellulose derivatives, ethylene/vinyl acetate copolymer, styrene/maleic anhydride copolymer, polymethacrylates, polysulfones, polyvinyl acetate phtalates, polylactic acids, polyglycolic acids and copolymers thereof, in an organic solvent, said solvent being a single organic compound which is at least partially miscible with water,

(c) mixing, with agitation, the solution of (a) with the solution of (b) to create an emulsion;

(d) adding water in sufficient quantity for all of the organic solvent to diffuse into the aqueous phase to cause the formation of microparticles of polymer in suspension in the aqueous phase;

(e) removing the excess solute and water-soluble macro-molecular substance by repeated washing with water, and then collecting and drying the microparticles.

2. The process according to claim 1, wherein aqueous solution of solute is a saturated or practically saturated solution.

3. The process according to either claims 1 or 2, characterized by the fact that the water-soluble macromolecular substance is a polysaccharide or a water-soluble polypeptide of natural origin or a water-soluble synthetic polymer.

4. The process according to any of claims 1 through 4 wherein that the solute is an electrolyte or a nonelectrolyte.

5. The process according to any of claims 1 or 2 wherein the fact that the organic solvent for the polymer is miscible with water in any proportion.

6. The process according to claim 1 including a stage of homogenizing the emulsion obtained in step (c).

7. A process for preparing a dispersion in the liquid phase of a powdered water-insoluble polymer, comprising suspending the polymer powder obtained by means of the process according to claim 1 in water.

9. The process according to claim 3 wherein the water-soluble synthetic polymer is polyvinyl alcohol.

10. The process according to claim 4 in which the electrolyte is a mineral salt.

8. A process for preparing a water-insoluble polymer in the liquid dispersion state, comprising the steps of:

(a) preparing a concentrated aqueous solution of a solute to which is added a water-soluble macro-molecular substance in a quantity sufficient to produce a viscous solution or a gel;

(b) separately preparing a solution of a water-insoluble polymer, said polymer selected from the group consisting of cellulose and cellulose derivatives, ethylene/vinyl acetate copolymer, styrene/maleic anhydride copolymer, polymethacrylates, polysulfones, polyvinyl acetate phtalates, polylactic acids, polyglycolic acids and copolymers thereof, in an organic solvent, said solvent consisting essentially of a single organic solvent which is at least partially miscible with water;

(c) mixing, with agitation, the aqueous mixture above in step (a) above with the organic polymer solution obtained in step (b) to create an emulsion;

(d) adding water in sufficient quantity for all of the organic solvent to diffuse into the aqueous phase of the resulting emulsion, to cause the formation of microparticles of polymer in suspension in the aqueous phase;

(e) eliminating the excess solute and water-soluble macro-molecular substance by repeated washing with water and then maintaining the washed micro-particles in suspension in a suitable portion of water.