3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it

• US 4,968,690 A
• Filed: 01/19/1989
• Issued: 11/06/1990
• Est. Priority Date: 05/27/1986
• Status: Expired due to Term

• Current Assignee: The United States Government As Represented By The Secretary Dept of Health and Human Services
• Original Assignee: The United States of America As Represented By The Secretary of Agriculture
• Inventors: Tseng, Christopher K., Marquez, Victor E., Glazer, Robert I., Haces, Alberto, Lim, Mu-Ill, Driscoll, John S.
• Primary Examiner(s): Rivers, Diana G.
• Application Number:
  US07/299,021
• Time in Patent Office: 656 Days
• Field of Search: 546/118, 514/303
• US Class Current: 514/303
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

The new compound 3-deazaneplanocin A has been discovered to have potent anti-viral, anti-tumor activity and differentiating activity. A simple method for preparing 3-deazaneplanocin A has been developed involving nucleophilic substitution, which method can also be used to prepare a great variety of carbocyclic nucleosides.

Claims

1. 3-Deazaneplanocin A.

3. A pharmaceutical composition for treating viral diseases comprising the compound of claim 1 and a pharmaceutically acceptable carrier.

2. A method of treating viral diseases wherein the viruses causing said viral diseases require a methylated 5'"'"'-cap structure on their m-RNA comprising administering an effective amount of 3-deazaneplanocin A.

4. A compound of the formula:

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