Compositions and methods for administering therapeutically active compounds
First Claim
1. A therapeutic composition comprising:
- (a) an effective amount of a therapeutically active compound having a molecular weight below about 5,000 and having an acidic functional group, which is normally eliminated from the body via the renal tubular secretion pathway for organic anions, and(b) at least one compound selected from the group consisting of the aldono-lactones of L-threonic acid, L-xylonic acid, L-lyxonic acid and the edible salts of L-threonic acid, L-sylonic acid and L-lyxonic acids, in an amount effective to increase the body absorption rate of said active compound.
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Abstract
A composition useful for administering therapeutically active compounds to improve the body absorption and/or retention thereof comprising a composition which includes a therapeutically active compound having a molecular weight below about 5,000 and having an acidic functional group, which is normally eliminated from the body via the renal tubular secretion pathway for organic anions, for example, Vitamin C, and at least one compound selected from the class consisting of L-threonic, L-xylonic and L-lyxonic acids, and the edible salts, aldono-lactones and aldono-lactides thereof.
A method for establishing and maintaining body levels of a therapeutically active compound which includes the step of administering a therapeutically effective dose of this composition.
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2 Claims
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1. A therapeutic composition comprising:
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(a) an effective amount of a therapeutically active compound having a molecular weight below about 5,000 and having an acidic functional group, which is normally eliminated from the body via the renal tubular secretion pathway for organic anions, and (b) at least one compound selected from the group consisting of the aldono-lactones of L-threonic acid, L-xylonic acid, L-lyxonic acid and the edible salts of L-threonic acid, L-sylonic acid and L-lyxonic acids, in an amount effective to increase the body absorption rate of said active compound. - View Dependent Claims (2)
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Specification