Intravenous system for delivering a beneficial agent
First Claim
1. An agent formulator for use in a parenteral fluid delivery system, the formulator comprising:
- (a) a chamber having fluid inlet and outlet means to maintain a continuous flow of the parenteral fluid therethrough, the chamber having a wall portion comprised of a material that (1) is permeable to a beneficial agent to be delivered into the fluid and (2) prevents convective flow of parenteral fluid therethrough, the wall portion having an interior surface and an exterior surface which is accessible from the exterior of the formulator;
(b) a flow distributor within the chamber for distributing the flow of parenteral fluid along the interior surface of the wall portion; and
(c) a transdermal-type agent delivery device attached to the exterior surface of the wall portion, the delivery device comprising a reservoir containing the beneficial agent, the reservior being releasably attached to the exterior surface of the wall portion;
wherein in operation, the fluid flowing through the chamber is distributed by the flow distributor along the interior surface of the wall portion, causing the agent to be delivered from the device through the wall portion and into the flowing fluid, the agent being delivered at a rate which is controlled substantially by the formulator and which is substantially independent of volumetric flow rate of the fluid flowing through the chamber.
1 Assignment
0 Petitions
Accused Products
Abstract
A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.
36 Citations
18 Claims
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1. An agent formulator for use in a parenteral fluid delivery system, the formulator comprising:
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(a) a chamber having fluid inlet and outlet means to maintain a continuous flow of the parenteral fluid therethrough, the chamber having a wall portion comprised of a material that (1) is permeable to a beneficial agent to be delivered into the fluid and (2) prevents convective flow of parenteral fluid therethrough, the wall portion having an interior surface and an exterior surface which is accessible from the exterior of the formulator; (b) a flow distributor within the chamber for distributing the flow of parenteral fluid along the interior surface of the wall portion; and (c) a transdermal-type agent delivery device attached to the exterior surface of the wall portion, the delivery device comprising a reservoir containing the beneficial agent, the reservior being releasably attached to the exterior surface of the wall portion; wherein in operation, the fluid flowing through the chamber is distributed by the flow distributor along the interior surface of the wall portion, causing the agent to be delivered from the device through the wall portion and into the flowing fluid, the agent being delivered at a rate which is controlled substantially by the formulator and which is substantially independent of volumetric flow rate of the fluid flowing through the chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for the controlled parenteral administration of beneficial agent to an animal, which method comprises:
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(a) allowing a pharmaceutically acceptable parenteral fluid, which is a carrier for the agent, to flow through an agent formulator with a chamber having an inlet in fluid communication with a container of the parenteral fluid and an outlet in fluid communication with the animal, the chamber also having a wall portion that (1) is permeable to the beneficial agent and (2) prevents convective flow of parenteral fluid therethrough, the wall portion having an interior surface and an exterior surface which is accessible from the exterior of the formulator; (b) a distributing the flow of parenteral fluid along the interior surface of the wall portion; and (c) releasably attaching a transdermal type agent delivery device to the exterior surface of the wall portion, the delivery device including a reservoir containing the beneficial agent; wherein in operation, the fluid flowing through the chamber is distributed along the interior surface of the wall portion, causing the agent to be delivered from the device through the wall portion and into the flowing fluid, thereby administering the agent to the animal in a beneficially effective amount over a prolonged period of time. - View Dependent Claims (16, 17, 18)
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Specification