Controlled release bases for pharmaceuticals
First Claim
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1. Extended action controlled release pharmaceutical composition for oral administration, comprising a pharmaceutically effective amount of a pharmaceutically active agent distributed in a controlled release core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being present in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol plus said acrylic resin.
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Abstract
The release of therapeutically active agents from controlled release bases is extended by using a combination of a higher aliphatic alcohol and an acrylic resin as the base material.
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15 Claims
- 1. Extended action controlled release pharmaceutical composition for oral administration, comprising a pharmaceutically effective amount of a pharmaceutically active agent distributed in a controlled release core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being present in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol plus said acrylic resin.
- 13. Core or matrix for controlled release pharmaceutical compositions for oral administration and being adapted for distribution therein of a pharmaceutically active agent, said core or matrix comprising a higher aliphatic alcohol of 10-18% carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol and said acrylic resin.
Specification