Device for sustained release of active substance
First Claim
1. A sustained release device for releasing active substance from a cavity, when such cavity contains the active substance, through a layer of hydrogel extending across at least one port in a wall made of water-impermeable material, which device comprises:
- a container having a wall formed from a water-impermeable material, the wall having at least one port therethrough, and which wall defines the cavity for the reception of active substance; and
within the container cavity, at least one body of hydrogel material, the hydrogel material, when in the dry state, being capable of being inserted into the container cavity and, when in the swollen condition, extending across the port or ports in the cavity wall and making sealing and pressing contact with the cavity wall adjacent the port or ports, said hydrogel material not being contiguous with the entire cavity wall.
1 Assignment
0 Petitions
Accused Products
Abstract
A device for the sustained release of active substance comprises a wall defining a cavity for the reception of active substance, the wall being of impermeable material and having one or more ports therethrough. Sections of hydrogel material are within the cavity, the hydrogel, in use, being swollen to cover the ports in the cavity wall. Active ingredient is released from the container only through the hydrogel covering the ports. In this way sustained and controlled release of the active substance from the device is obtained.
69 Citations
14 Claims
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1. A sustained release device for releasing active substance from a cavity, when such cavity contains the active substance, through a layer of hydrogel extending across at least one port in a wall made of water-impermeable material, which device comprises:
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a container having a wall formed from a water-impermeable material, the wall having at least one port therethrough, and which wall defines the cavity for the reception of active substance; and within the container cavity, at least one body of hydrogel material, the hydrogel material, when in the dry state, being capable of being inserted into the container cavity and, when in the swollen condition, extending across the port or ports in the cavity wall and making sealing and pressing contact with the cavity wall adjacent the port or ports, said hydrogel material not being contiguous with the entire cavity wall. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A sustained release device for releasing active substance from a cavity containing the active substance, through a layer of hydrogel extending across at least one port in a wall made of water-impermeable material, which device comprises:
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a container having a wall formed from a water-impermeable material, the wall having at least one port therethrough, and which wall defines the cavity which contains said active substance; and within the container cavity, at least one body of hydrogel material, when in the dry state, being capable of being inserted into the container cavity and, when in the swollen condition, making sealing contact with the cavity wall adjacent the port or ports, said hydrogel material not being contiguous with the entire cavity wall. - View Dependent Claims (10, 13, 14)
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11. A method of administering active substance to a patient which method comprises implanting into or introducing into the patient'"'"'s body a sustained release device for releasing active substance from a cavity containing the active substance through a layer of hydrogel covering at least one port in a wall made of water-impermeable material, wherein the wall defines the cavity and the cavity contains active substance and at least one body of hydrogel material which hydrogel material when in swollen condition is not contiguous with the entire cavity wall but covers the port or ports in the wall, and maintaining the hydrogel material in swollen condition, the active substance being released from the cavity through the hydrogel layer covering the port or ports into the patient'"'"'s body.
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12. A method of treating thalassaemia which method comprises implanting into or introducing into a patient'"'"'s body a sustained release device for releasing active substance from a cavity containing the active substance through a layer of hydrogel covering at least one port in a wall made of water-impermeable material, wherein the wall defines the cavity and the cavity contains desferrioxamine in aqueous solution and at least one body of hydrogel material which hydrogel material when in swollen condition is not contiguous with the entire cavity wall but covers the port or ports in the wall, the desferrioxamine being released from the cavity through the hydrogel layer covering the port or ports into the patient'"'"'s body.
Specification