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Drug delivery system

  • US 4,973,469 A
  • Filed: 08/17/1989
  • Issued: 11/27/1990
  • Est. Priority Date: 02/03/1986
  • Status: Expired due to Term
First Claim
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1. A controlled release formulation comprising an adsorbate of a mixture of 1 part by weight of a pharmaceutically useful active ingredient in substantially amorphous form and from 0.1 to 10 parts by weight of an inactive substance adsorbed on a cross-linked polymer in a ratio of 1 part by weight of said mixture to 0.5-20 parts by weight of cross-linked polymer, said inactive substance being selected to modify the dissolution of the active drug from the cross-linked polymer in vivo, wherein the inactive substance is a substance whose solubility in aqueous media is inversely proportional to that of the active ingredient, with the proviso that the active ingredient is not a dihydropyridine when the inactive substance is polyvinylpyrrolidone with an average molecular weight in the range 15,000 to 50,000 and the cross-linked polymer is cross-linked polyvinylpyrrolidone.

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