Implant for percutaneous sampling of serous fluid and for delivering drug upon external compression

• US 4,976,695 A
• Filed: 06/29/1988
• Issued: 12/11/1990
• Est. Priority Date: 04/07/1988
• Status: Expired due to Fees

• Current Assignee: Paul Y. Wang
• Original Assignee: Paul Y. Wang
• Inventors: Wang, Paul Y.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): SHAY, RANDY CITRIN
• Application Number:
  US07/213,092
• Time in Patent Office: 895 Days
• Field of Search: 418/153, 604/132, 604/133, 604/896, 604/891.1, 604/93, 604/175, 604/181, 604/183
• US Class Current: 604/132
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 2039/0211 with multiple chambers in a single site
• CPC Class Codes: A61M 2202/0042 filtrate, i.e. the fluid passing through the filter
• CPC Class Codes: A61M 2202/0415 Plasma
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276

Abstract

An implant comprises interconnected compartments with intlet and outlet and can be used for sampling of entered serous fluid or to hold drug concentrate for selective delivery, if desired. The compartments are formed by sealing around porous foam rings between a top and a bottom layer of biocompatible elastic membrane with a polymer paste which sets to form a rubbery shell. The top membrane layer over the compartment is punctured to create a small resealable channel. Upon subcutaneous implantation, serous fluid under hydrostatic pressure seeps into the interior through the puncture orifice. The entered fluid may be withdrawn by an hypodermic syringe through the rubbery side wall to obtain serum-borne bioactive materials. If a drug concentrate is included, the entered fluid will dissolve some of the drug therein. When delivery is required, external sidewise compression of the elastic compartment over the skin fold expels the drug containing solution therein through the orifice.

Claims

1. A self contained implantable device having a porous central body and an external self-sealing skin which is easily penetrable by a needle, said skin having a resealable orifice, whereby said central body comprises a reservoir compartment for serous fluid and said orifice permits serous fluid entry after implantation.

2. A self contained implantable device as claimed in claim 1 wherein the central body comprises a plurality of interconnected porous sections.

3. A self contained implantable device as claimed in claim 2 wherein said central body comprises foam.

4. A self contained implantable device as claimed in claim 3 in which said central body is formed by a pair of foam rings having a figure 8 cross section.

5. A self contained implantable device as claimed in claim 3 wherein a porous section contains a bioactive substance.

6. A self contained implantable device as claimed in claim 2 wherein a porous section contains a bioactive substance.

7. A self contained implantable device as claimed in claim 6 wherein said bioactive substance if a solid.

8. A self contained implantable device as claimed in claim 6 wherein said bioactive substance is carried within a penetrable relatively rigid structure disposed within said porous section.

9. A self contained implantable device as claimed in claim 6 wherein the bioactive substance is a polypeptide hormone.

10. A self contained implantable device as claimed in claim 6 wherein the polypeptide hormone is insulin, somatotropin, somatomedin, or mixture thereof.

11. A self contained implantable device as claimed in claim 6 wherein the bioactive substance is steroid hormone.