Coated biomaterials and methods for making same
First Claim
1. A biomaterial comprising a base portion consisting essentially of calcium carbonate and having a surface layer of synthetic phosphate.
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Abstract
Biomaterials useful for onthopedicanel dental applications is disclosed. These materials have a base portion of calcium carbonate and a surface layer of a synthetic phosphate such as hydroxyapatite. The base portion may be a calcium carbonate structure having three-dimensional interconnected porosity such as may be found in porous skeletal carbonate of marine life, e.g. coral porites skeletal aragonite, or it may be porous or non-porous granules of calcium carbonate.
A method for making the biomaterials is also disclosed. The synthetic phosphate surface is made using a hydroconversion reaction with a soluble or solubilized phosphate such as ammonium dibasic phosphate ((NH4)2 HPO4).
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Citations
32 Claims
- 1. A biomaterial comprising a base portion consisting essentially of calcium carbonate and having a surface layer of synthetic phosphate.
- 23. A synthetic biomaterial characterized by a substantially uniform pore volume in the range from about 10% to about 90% and having a microstructure characterized by a pronounced three dimensional fenestrate structure corresponding to the microstructure of the porous carbonate echinoderm or schleractinian coral skeletal material of marine life and providing a periodic minimal surface, said periodic minimal surface dividing the volume of said material into two interpenetrating regions, each of which is a single, multiply connected domain, said material having a substantially uniform pore size diameter and substantially uniform pore connection or openings in the range from about 5 microns to about 1000 microns, said synthetic material comprising a base portion of calcium carbonate and a surface layer of calcium phosphate.
Specification