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Biodegradable polypeptide and the use thereof for the gradual release of drugs

  • US 4,976,962 A
  • Filed: 07/11/1989
  • Issued: 12/11/1990
  • Est. Priority Date: 10/19/1984
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition comprising an effective amount of a drug carried by a polypeptide comprising a member of the group consisting of (a) polymers corresponding to the formula ##STR15## in which R1 is a lower alkyl or hydrogen, R being an aliphatic or aromatic radical or R and R1 are bound to one another to form a hydrocarbon bridge of two or three links which may or may not be substituted;

  • and (b) polymers corresponding to the formula;

    ##STR16## wherein the groups R and R1 have the meanings given above and wherein ##STR17## is an uncarboxylated or carboxylated amino acid moiety of which the --COOH is free or partially or completely esterified;

    n is 1 to 2 and x is equal to y+z is selected so that the molecular weight of the polypeptide is not less than 5000 D, the drug being progressively released as a result of the biodegradation of the polypeptide carrier.

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