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Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents

  • US 4,977,178 A
  • Filed: 07/19/1989
  • Issued: 12/11/1990
  • Est. Priority Date: 09/20/1982
  • Status: Expired due to Term
First Claim
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1. A method of treating anxiety in a hyperanxious person which comprises treating said person with an anxiolytic amount of a compound of the formula ##STR8## wherein, in a first alternative,A2 is hydrogen or methyl, and B1 and C1 are each independently hydrogen, (C1 -C2)alkyl, phenyl or benzyl;

  • in a second alternative,A2 is hydrogen or methyl, and B1 and C1 together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine, morpholine or imidazole ring;

    in a third alternative,A2 and B1 together are 1,3-propylene, 1,4-butylene or 1,5-pentylene, and C1 is hydrogen, (C1 -C2)alkyl, phenyl or benzyl;

    W is hydrogen, (C1 -C2)alkyl, (C1 -C2)alkoxy, chloro or fluoro;

    W1, X1 and Y1 are each independently hydrogen, (C1 -C2)alkyl, (C1 -C2)alkoxy, (C1 -C2)alkylthio, bromo, chloro, fluoro, trifluoromethyl, hydroxy, formyl, carboxamido, (C1 -C2)alkylcarboxamido, di(C1 -C2)alkylcarboxamido, cyano, nitro, amino, (C1 -C2)alkylamino or di(C1 -C2)alkylamino;

    with the proviso that when A2 is hydrogen or methyl, B1 and C1 are each independently hydrogen, (C1 -C2)alkyl, phenyl or benzyl, and any one of W1, X1 and Y1 is 4-chloro, at least one of W1, X1 and Y1 is other than hydrogen.

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