Article having non-crosslinked crystallized polymer coatings

• US 4,977,901 A
• Filed: 04/06/1990
• Issued: 12/18/1990
• Est. Priority Date: 11/23/1988
• Status: Expired due to Term

• Current Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Ofstead, Ronald F.
• Primary Examiner(s): Schofer, Joseph L.
• Assistant Examiner(s): Guarriello, John J.
• Application Number:
  US07/505,411
• Time in Patent Office: 256 Days
• Field of Search: 428/379, 428/457, 428/463, 128/657, 128/772, 606/76
• US Class Current: 600/585
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/0029 using an intermediate layer of polymer
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: Y10T 428/294 including metal or compound thereof [excluding glass, ceramic and asbestos]
• CPC Class Codes: Y10T 428/31678 Of metal
• CPC Class Codes: Y10T 428/31699 Ester, halide or nitrile of addition polymer

Abstract

A non-crosslinked crystallized polymer or polymer blending coating is disclosed for articles that come into contact with bodily fluids. The polymer or polymer blend to be used is crystallizable and is stable in the presence of water at temperatures of up to about 60° C. when in the crystalline state. The polymer or polymer blend is dissolved in a solvent, such as water or dimethyl sulfoxide (DMSO), and is coated on the article. The polymer coating is then crystallized, generally by heat treatment, providing both toughness and increased adherence of the coating to the article without ready dissolution when the article comes into contact with fluids.

Claims

1. An article that comes into contact with bodily fluids wherein being slippery when wet is a desirable property of the article, which article is coated by a non-crosslinked, crystallized polymer or polymer blend comprising poly(vinyl alcohol) wherein said polymer or polymer blend is soluble before crystallization in water or DMSO at temperatures less than about 100°

C., and is stable in the presence of water at temperatures of up to about 60°

C.

2. An article of claim 1 which is a guidewire.

3. An article of claim 1 which is an implant for the body.

4. An article of claim 1 wherein the implant is designed to be implanted in a blood vessel.

5. The article of claim 1 wherein the polymer has a degree of crystallinity of between about 30 and about 50 percent.

6. The article of claim 5 wherein the polymer has a degree of crystallinity of between about 40 and about 45 percent.

7. An article of claim 1 wherein the poly(vinyl alcohol) polymer is more than 88% hydrolyzed before crystallization.

8. An article of claim 1 wherein the poly(vinyl alcohol) polymer has a molecular weight of between about 14,000 and about 1,000,000.

9. An article of claim 1 wherein the poly(vinyl alcohol) polymer has a molecular weight of about 40,000 to about 126,000.

10. An article of claim 1 wherein the poly(vinyl alcohol) polymer has a molecular weight of about 80,000 to about 115,000.

11. An article of claim 1 which additionally comprises heparin.

12. An article of claim 1 which additionally comprises a dye or tint.

13. An article of claim 12 wherein the dye is covalently bonded to the poly(vinyl alcohol) polymer.