Polyionene-transformed microporous membrane

• US 4,980,067 A
• Filed: 11/28/1988
• Issued: 12/25/1990
• Est. Priority Date: 07/23/1985
• Status: Expired due to Fees

• Current Assignee: Cuno Incorporated
• Original Assignee: Cuno Incorporated
• Inventors: Hou, Chung-Jen, Hou, Kenneth C., Chen, Haunn-Lin
• Primary Examiner(s): Spear, Frank
• Application Number:
  US07/276,831
• Time in Patent Office: 757 Days
• Field of Search: 210/638, 210/500.38, 210/490, 427/244, 427/245, 427/246, 435/240, 435/243, 435/256.1, 435/254, 435/287, 526/238.2
• US Class Current: 210/638
• CPC Class Codes: B01J 20/28033 Membrane, sheet, cloth, pad, lamellar or mat
• CPC Class Codes: B01J 20/28052 Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 20/2808 being less than 2 nm, i.e. micropores or nanopores
• CPC Class Codes: B01J 20/321 consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3212 consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3217 Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
• CPC Class Codes: B01J 20/327 Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3272 Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3278 Polymers being grafted on the carrier
• CPC Class Codes: B01J 39/22 Cellulose or wood; Derivatives thereof
• CPC Class Codes: B01J 41/16 Cellulose or wood; Derivatives thereof
• CPC Class Codes: B01J 47/127 in the form of filaments or fibres
• CPC Class Codes: C08F 251/00 Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
• CPC Class Codes: C08G 81/02 at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds

Abstract

A microporous membrane modified by coating or grafting thereon a polyionene material. The thus-modified microporous membrane is useful for separating microorganism-originated contaminants from biological liquids.

Claims

1. A modified microporous membrane comprising a polyionene-transformed hydrophilic organic polymeric microporous membrane having bonded thereto an amount of polyionene effective to adsorb and inactivate contaminants of microorganism origin.

2. The modified membrane of claim 1 wherein said polyionene comprises a water-soluble polymer having polycauternary ammonium groups separated by hydrophobic groups.

3. The modified microporous membrane of claim 1 wherein said polyionene comprises a polymer having the following repeating units:

##STR19## wherein R¹ and R² are C₁ -C₄ alkyl;

L is --(CH₂)_n --P--(CH₂)_m ;

M is --(CH₂)_o --Q--(CH₂)_p --, with P and Q being the same or different and representing at least one of CH₂, CHA, pyridine, C₆ H₄, C₆ H₃ A, C₆ H₄ --CHA--C₆ H₄ or R₃ C₆ H₂ A wherein R₃ is C₁ -C₄ alkyl;

m, n, o and p representing integers from 1 to 20; and

A represents a reactive group selected from hydroxy, carboxyl, halo, amino, epoxy and aldehyde.

4. The modified microporous membrane of claim 3 wherein R¹ and R² are methyl, L is (CH₂)₆ and M is at least one of (CH₂)₁₀ and a mixture of (CH₂)₁₀ and CH₂ --CHOH--CH₂.

5. The modified microporous membrane of claim 1 wherein said hydrophilic organic polymeric microporous membrane is coated with said polyionene.

6. The modified microporous membrane of claim 1 wherein said hydrophilic organic polymeric microporous membrane is covalently bonded to said polyionene.

7. The modified microporous membrane of claim 1 wherein said hydrophilic organic polymeric microporous membrane is nylon.

8. A modified microporous membrane comprising a symmetrical, isotropic, porous hydrophilic organic polymeric microporous membrane having bonded to substantially all of the wetted surfaces thereof an amount of polyionene effective to adsorb and inactivate contaminants of microorganism origin, wherein said polyionene comprises a water-soluble polymer having polyQuaternary ammonium groups separated by hydrophobic groups.

9. The modified microporous membrane of claim 8 wherein said polyionene comprises a polymer having the following repeating units:

##STR20## wherein R¹ and R² are C₁ -C₄ alkyl;

L is --(CH₂)_n --P--(CH₂)_m ;

M is --(CH₂)_o --Q--(CH₂)_p --, with P and Q being the same or different and representing at least one of CH₂, CHA, C₆ H₄, pyridine, C₆ H₃ A, C₆ H₄ --CHA--C₆ H₄, or R³ C₆ H₂ A wherein R³ is C₁ -C₄ alkyl;

m, n, o and p representing integers from 1 to 20; and

A represents a reactive group selected from hydroxy, carboxyl, halo, amino, epoxy and aldehyde.

10. The modified microporous membrane of claim 9 wherein R¹ and R² are methyl, L is (CH₂)₆ and M is at least one of (CH₂)₁₀ and a mixture of (CH₂)₁₀ and CH₂ --CHOH--CH₂.

11. The modified microporous membrane of claim 8 wherein said hydrophilic organic polymeric microporous membrane is nylon.

12. A method for separating and inactivating microorganism-originated contaminants from a biological liquid comprising passing said biological liquid through a polyionene-transformed hydrophilic organic polymeric microporous membrane having bonded thereto an amount of polyionene effective to adsorb and inactivate contaminants of microorganism origin.

13. The method of claim 12 wherein said polyionene comprises:

##STR21## wherein R¹ and R² are C₁ -C₄ alkyl;

L is --(CH₂)_n --P--(CH₂)_m ;

M is --(CH₂)_o --Q--(CH₂)_p --, with P and Q being the same or different and representing at least one of CH₂, CHA, C₆ H₄, pyridine, C₆ H₃ A, C₆ H₄ --CHA--C₆ H₄, or R³ C₆ H₂ A wherein R³ is C₁ -C₄ alkyl; and

m, n, o and p representing integers from 1 to 20; and

A represents a reactive group selected from hydroxy, epoxy, carboxy, amino, halo or aldehyde.

14. The method of claim 12 wherein R¹ and R₂ are methyl.

15. A method for separating microorganism-originated contaminants from a biological liquid comprising passing said biological liquid through a modified microporous membrane comprising a hydrophilic organic polymeric microporous membrane having bonded to substantially all the wetted surfaces thereof an amount of polyionene effective to adsorb and inactivate contaminants of microorganism origin, said polyionene comprising a water-soluble polymer having polyquaternary ammonium groups separated by hydrophobic groups.

16. The method of claim 15 wherein said polyionene comprises a polymer having the following repeating units:

##STR22## wherein R¹ and R² are C₁ -C₄ alkyl;

L is --(CH₂)_n --P--(CH₂)_m ;

M is --(CH₂)_o --Q--(CH₂)_p --, with P and Q being the same or different and representing at least one of CH₂, CHA, C₆ H₄, pyridine, C₆ H₃ A, C₆ H₄ --CHA--C₆ H₄, or R³ C₆ H₂ A wherein R³ is C₁ -C₄ alkyl;

m, n, o and p representing integers from 1 to 20; and

A represents a reactive group selected from hydroxy, carboxyl, halo, amino, epoxy and aldehyde.

17. The process of claim 15 wherein an R¹ and R² are methyl, L is (CH₂)₆ and M is at least one of (CH₂)₁₀ and a mixture of (CH₂)₁₀ and CH₂ --CHOH--CH₂.

18. A separation device comprising a housing and a separation medium wherein said separation medium comprises a polyionene-transformed hydrophilic organic microporous membrane having bonded thereto an amount of polyionene effective to adsorb and inactive contaminants of microorganism origin.

19. The separation device of claim 18, wherein said polyionene comprises a water-soluble polymer having polyquaternary ammonium groups separated by hydrophobic groups.

20. The separation device of claim 18, wherein said polyionene comprises a polymer having the following repeating units:

##STR23## wherein R¹ and R² are C₁ -C₄ alkyl;

L is --(CH₂)_n --P--(CH₂)_m ;

M is --(CH₂)_o --Q--(CH₂)_p --, with P and Q being the same or different and representing at least one of CH₂, CHA, pyridine, C₆ H₄, C₆ H₃ A, C₆ H₄ --CHA--C₆ H₄, or R³ C₆ H₂ A wherein R³ is C₁ -C₄ alkyl;

m, n, o and p representing integers from 1 to 20; and

A represents a reactive group selected from hydroxy, carboxyl, halo, amino, epoxy and aldehyde.

21. The separation device of claim 18 wherein said microporous membrane is nylon.

22. The separation device of claim 18 wherein said microporous membrane is coated with said polyionene.

23. The separation device of claim 18 wherein said microporous membrane is covalently bonded to said polyionene.

24. The separation device of claim 18 wherein said separation medium comprises a cylinder which is pleated over its entire length and wherein said housing comprises a foraminous cylindrical core member, a foraminous cylindrical outer member and two end caps, said separation medium interposed between said foraminous cylindrical core member and said foraminous cylindrical outer member and sealed to each of said end caps.

25. A method for producing a microporous membrane comprising modifying said membrane with an amount of polyionene, said amount being effective to adsorb and inactivate contaminants of microorganism origin.

26. The method of claim 25 wherein said microporous membrane is coated with said polyionene.

27. The method of claim 25 wherein said microporous membrane is grafted with said polyionene.

28. The method of claims 25, 26 or 27 wherein said polyionene comprises a water-soluble polymer having polyquaternary ammonium groups separated by hydrophobic groups.

29. The method of claim 28 wherein said polyione comprises a polymer having the following repeating units:

##STR24## wherein R¹ and R² are C₁ -C₄ alkyl;

L is --(CH₂)_n --P--(CH₂)_m ;

M is --(CH₂)_o --Q--(CH₂)_p --, with P and Q being the same or different and representing at least one of CH₂, CHA, pyridine, C₆ H₄, C₆ H₃ A, C₆ H₄ --CHA--C₆ H₄, or R³ C₆ H₂ A wherein R³ is C₁ -C₄ alkyl;

m, n, o and p representing integers from 1 to 20; and

A represents a reactive group selected from hydroxy, carboxyl, halo, amino, epoxy and aldehyde.