Methods for enhancing magnetic resonance imaging

• US 4,980,148 A
• Filed: 02/06/1985
• Issued: 12/25/1990
• Est. Priority Date: 02/06/1985
• Status: Expired due to Fees

• Current Assignee: Mallinckrodt Medical Inc. (Mallinckrodt plc)
• Original Assignee: Mallinckrodt Incorporated (Mallinckrodt plc)
• Inventors: Dean, Richard T.
• Primary Examiner(s): Raymond, Richard L.
• Application Number:
  US06/698,895
• Time in Patent Office: 2,148 Days
• Field of Search: 260/479 J, 224/309, 128/653, 128/654, 424/9, 534/13
• US Class Current: 424/9.364
• CPC Class Codes: A61K 49/06 Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Abstract

Substantially nontoxic manganese or gadolinium complexes of compounds of the formula: ##STR1## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3, and x is selected from the group consisting of O, S, CHOH and CHSH, are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative manganese and gadolinium complexes of such compounds include disodium [[ethylenebis(oxyethylenenitrilo)]tetraaceto]-manganese(II), disodium [[(2-hydroxytrimethylene)dinitrilo]-tetraaceto]manganese(II), sodium [[(2-hyroxytrimethylene)dinitrilo]tetraaceto)gadolinium(III).

Claims

1. A method for enhancing magnetic resonance images of body organs and tissues which comprises administering to a mammal a composition comprising a substantially nontoxic manganese or gadolinium complex of a compound of the formula:

##STR4## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3 and X is selected from the group consisting of O, S, CHOH and CHSH, in a sufficient amount to provide enhancement of magnetic resonance images of body organs and tissues.

2. A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim 1 wherein said complex is disodium [[ethylenebis(oxyethylenenitrilo)]tetraaceto]manganese(II).

3. A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim 1 wherein said complex is disodium [[(2-hydroxytrimethylene)dinitrilo]tetraaceto]manganese(II).

4. A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim, 1 wherein said complex is sodium [[(2-hydroxytrimethylene)dinitrilo]tetraaceto]gadolinium(III).

5. A method for enhancing magnetic resonance images of body organs and tissues as set forth in claim 1 wherein magnetic resonance images of the hepatobiliary system are enhanced.