Protected nucleosides which permit more efficient oligonucleotide syntheses
First Claim
1. A nucleoside having the formula:
- wherein B is a divalent group chosen from among;
##STR33## connected to the CO group by its exocyclic NH group;
R1 is hydrogen,R2 is a group selected from the group consisting of methoxy, phenoxy, chlorophenoxy and fluorophenoxy,R3 is selected from the group consisting of hydrogen, 9-phenyl xanthenyl, trityl of formula;
##STR34## wherein R6, R7 and R8, which may be the same or different, are hydrogen, methyl, ethyl or methoxy, and the group ##STR35## wherein R1 and R2 have the meanings given above;
R4 is a hydrogen, a phosphorylated group selected from the group consisting of ##STR36## or the group ##STR37## wherein R1 and R2 have the meanings given above; and
R5 is a hydrogen or hydroxyl group.
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Accused Products
Abstract
The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides.
These derivatives are in accordance with the formula: ##STR1## in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group ##STR2## with R1 representing a hydrogen atom or an alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical ##STR3## R4 represents a hydrogen atom, the radical of formula: ##STR4## or a radical suitable for the synthesis of polynucleotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.
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Citations
12 Claims
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1. A nucleoside having the formula:
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wherein B is a divalent group chosen from among;
##STR33## connected to the CO group by its exocyclic NH group;
R1 is hydrogen,R2 is a group selected from the group consisting of methoxy, phenoxy, chlorophenoxy and fluorophenoxy, R3 is selected from the group consisting of hydrogen, 9-phenyl xanthenyl, trityl of formula;
##STR34## wherein R6, R7 and R8, which may be the same or different, are hydrogen, methyl, ethyl or methoxy, and the group ##STR35## wherein R1 and R2 have the meanings given above;
R4 is a hydrogen, a phosphorylated group selected from the group consisting of ##STR36## or the group ##STR37## wherein R1 and R2 have the meanings given above; and
R5 is a hydrogen or hydroxyl group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification