Apovincaminic acid derivatives

• US 4,980,474 A
• Filed: 09/12/1989
• Issued: 12/25/1990
• Est. Priority Date: 09/30/1988
• Status: Expired due to Fees

• Current Assignee: Taisho Pharmaceutical Company Limited (Taisho Pharmaceutical Holdings Company Limited)
• Original Assignee: Taisho Pharmaceutical Company Limited (Taisho Pharmaceutical Holdings Company Limited)
• Inventors: Hayashi, Masatoshi, Hatayama, Katsuo, Yokomori, Sadakazu, Nakashima, Yoshimoto
• Primary Examiner(s): Berch, Mark L.
• Assistant Examiner(s): CHANG, CELIA C
• Application Number:
  US07/405,972
• Time in Patent Office: 469 Days
• Field of Search: 546/43, 546/51, 514/283
• US Class Current: 546/51
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07D 461/00 Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine dimeric indolo alkaloids C07D519/04

Abstract

An apovincaminic acid derivative represented by the formula ##STR1## wherein n is an integer of from 2 to 11, and a pharmaceutically acceptable salt thereof are disclosed. These compounds are useful for therapy of cerebrovascular injuries, peripheral vessel injuries, angina pectoris, hypertension and senile dementia.

Claims

1. An apovincaminic acid derivative represented by the formula ##STR3## wherein n is an integer of from 2 to 11, and a pharmaceutically acceptable salt thereof.

2. 2-Nitroxyethyl apovincaminate.

3. 3-Nitroxy-n-propyl apovincaminate.