Endoscopic fiberoptic fluorescence spectrometer

• US 4,981,138 A
• Filed: 06/30/1988
• Issued: 01/01/1991
• Est. Priority Date: 06/30/1988
• Status: Expired due to Fees

• Current Assignee: Yale University
• Original Assignee: Yale University
• Inventors: O'Brien, Kenneth M., Kapadia, Cyrus R., Stetz, Mark L., Deckelbaum, Lawrence I.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Hanley, John C.
• Application Number:
  US07/213,414
• Time in Patent Office: 915 Days
• Field of Search: 128/633, 128/634, 128/664, 128/665, 128/303.1
• US Class Current: 600/477
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: G02B 6/4296 coupling with sources of high radiant energy, e.g. high power lasers, high temperature light sources

Abstract

A method of detecting pre-malignant lesions in the gastrointestinal tract comprises positioning an opitcal fiber in a patient'"'"'s gastrointestinal tract and transmitting ultraviolet laser light through said optical fiber means to cause the tissue of the gastrointestinal tract illuminated by the laser to fluoresce in the near visible band of frequencies. The fluorescence spectrum is returned through the optical fiber to a spectrum analyzing means which analyzes the spectrum in the wavelength range of 350 to 700 nm to determine whether the tissue caused to fluoresce is pre-malignant. Tissue so diagnosed may be ablated by a high power laser using the same fiberoptic system.

Claims

1. A method of detecting pre-malignant tissue, comprising positioning an optical fiber adjacent the tissue to be diagnosed, transmitting ultraviolet laser light through said optical fiber means to cause the tissue illuminated by said laser to fluoresce in the visible band of wavelengths, transmitting the fluorescence spectrum back through said optical fiber means to a spectrum analyzing means, and analyzing the spectrum at least in the wavelength range of 350 to 500 nm to determine whether the tissue caused to fluoresce is pre-malignant.

2. A method of detecting pre-malignant tissue in the gastrointestinal tract, comprising positioning an optical fiber means in a patient'"'"'s gastrointestinal tract, passing ultraviolet laser light through said optical fiber means to cause the tissue of the gastrointestinal tract illuminated by said laser to fluoresce in the visible band of frequencies, transmitting the fluorescence spectrum back through said optical fiber means to a spectrum analyzing means, and analyzing the spectrum at least in the wavelength range of 350 to 500 nm to determine whether the tissue caused to fluoresce is pre-malignant.

3. A method of detecting pre-malignant tissue according to claim 2, wherein said optical fiber means is positioned by inserting it through an endoscope.

4. A method of ablating pre-malignant tissue in the gastrointestinal tract, comprising positioning an optical fiber means in a patient'"'"'s gastrointestinal tract, passing ultraviolet laser light through said optical fiber means to cause the tissue of the gastrointestinal tract illuminated by said laser to fluoresce in the near visual band of frequencies, transmitting the fluorescence spectrum back through said optical fiber means to a spectrum analyzing means, analyzing the spectrum at least in the wavelength range of 350 to 500 nm to determine whether the tissue caused to fluoresce is pre-malignant, and ablating the tissue diagnosed as pre-malignant.

5. A method of ablating pre-malignant tissue in the gastrointestinal tract according to claim 4, wherein said optical fiber means is positioned by inserting it through an endoscope.

6. A method of ablating pre-malignant tissue in the gastrointestinal tract according to claim 5, wherein the tissue is ablated without charring.