Polylactide compositions

• US 4,981,696 A
• Filed: 11/20/1989
• Issued: 01/01/1991
• Est. Priority Date: 12/22/1986
• Status: Expired due to Fees

• Current Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Original Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Inventors: Murdoch, Joseph R., Loomis, Gary L.
• Primary Examiner(s): Foelak, Morton
• Application Number:
  US07/438,123
• Time in Patent Office: 407 Days
• Field of Search: 424/78, 424/423, 424/425, 424/426, 424/486
• US Class Current: 424/486
• CPC Class Codes: A61L 17/12 Homopolymers or copolymers of glycolic acid or lactic acid
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: C08G 63/08 Lactones or lactides
• CPC Class Codes: C08J 2367/00 Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain of polyester-amides C08J2377/12; of polyester-imides C08J2379/08; Derivatives of such polymers
• CPC Class Codes: C08J 5/18 Manufacture of films or sheets
• CPC Class Codes: C08J 9/28 by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: D01F 6/625 derived from hydroxy-carboxylic acids, e.g. lactones

Abstract

Systems for delivery of biologically active materials employing novel polylactide composition containing segments of poly(R-lactide) interlocked with segments of poly(S-lactide) as the carrier.

Claims

1. A system for controlled delivery of biologically active ingredients wherein the ingredients contained in a polymeric composition comprising segments of poly(R-lactide) interlocked with segments of poly(S-lactide).

2. The composition of claim 1 wherein the molar ratio of R-lactide units to S-lactide units is in the range of about 1:

99 to 99;

1.

3. The composition of claim 2 wherein the molar ratio of R-lactide units to S-lactide units is in the range of about 1:

9 to 9;

1.

4. The composition of claim 3 wherein the molar ratio is about 1:

1.

5. The composition of claim 2 consisting essentially of segments of poly(R-lactide) and segments of poly(S-lactide), each segment having a number average molecular weight of at least about 300.

6. The composition of claim 5 wherein the number average molecular weight is in the range of about 70,000-90,000.

7. The compositions of claim 1 wherein the biologically active ingredient is a drug which is held by encapsulation.

8. The compositions of claim 6 wherein the biologically active ingredient is a drug which is held by encapsulation.

9. The system of claim 7 wherein the composition melts higher than either of the segments.