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Oligonucleotides with modified phosphate and modified carbohydrate moieties at the respective chain termini

  • US 4,981,957 A
  • Filed: 07/18/1985
  • Issued: 01/01/1991
  • Est. Priority Date: 07/19/1984
  • Status: Expired due to Fees
First Claim
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1. An oligonucleotide of the formula ##STR77## in which Y and T are identical or different and are O, S, Se or NH, Z and W are identical or different and are O, S or NH, at least one of the substituents Y and Z in at least one of the phosphate moieties being different from oxygen, X is selected from the group consisting of ##STR78## R is H or ##STR79## R1 is alkyl of 1 to 5 carbon atoms or phenyl, Σ

  • is a whole number equal ton when X is --CHOHCH2 OR, orn-1 when X is ##STR80## wherein n is an integer of 2 to 10, m is an integer of 1 to 3, and A is adenine or a derivative selected from the group consisting of ##STR81## and the physiologically acceptable salts thereof.

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