Controlled release combination of carbidopa/levodopa
First Claim
1. A controlled release solid oral dosage formulation consisting essentially of a uniform dispersion of 5-300 mg of carbidopa, 20-1200 mg of levodopa in a polymer vehicle of 2 to 120 mg of polymethyl methacrylate, whereby following administration the carbidopa and levodopa are released slowly and simultaneously from the formulation.
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Accused Products
Abstract
A matrix or monolithic drug delivery system for the controlled release of carbidopa and levodopa consists of the two drugs uniformly dispersed in a polymer vehicle at a concentration that is greater than the solubility of either drug in the polymer. Treatment of parkinsonism with the controlled release formulation provides several advantages over treatment with the standard carbidopa/levodopa combination presently employed.
92 Citations
3 Claims
- 1. A controlled release solid oral dosage formulation consisting essentially of a uniform dispersion of 5-300 mg of carbidopa, 20-1200 mg of levodopa in a polymer vehicle of 2 to 120 mg of polymethyl methacrylate, whereby following administration the carbidopa and levodopa are released slowly and simultaneously from the formulation.
Specification
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- Resources
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Current AssigneeMerck & Co., Inc.
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Original AssigneeMerck & Co., Inc.
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InventorsScholtz, Edward C., Nibbelink, Donald W., Dempski, Robert E., Reines, Scott A.
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Primary Examiner(s)Rose, Shep K.
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Application NumberUS07/444,222Time in Patent Office403 DaysField of Search424/469, 424/470, 424/81, 424/486, 424/487US Class Current514/565CPC Class CodesA61K 31/19 Carboxylic acids, e.g. valp...A61K 31/195 having an amino groupA61K 9/2027 obtained by reactions only ...A61K 9/2054 Cellulose; Cellulose deriva...
