Method and apparatus for identifying and alleviating semantic memory deficiencies

• US 4,984,578 A
• Filed: 05/07/1990
• Issued: 01/15/1991
• Est. Priority Date: 11/14/1988
• Status: Expired due to Term

• Current Assignee: William Keppel
• Original Assignee: Kenneth R. Erickson, William Keppel
• Inventors: Erickson, Kenneth R., Keppel, William
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US07/519,952
• Time in Patent Office: 253 Days
• Field of Search: 128/731, 128/732, 128/733, 128/745, 364/413.02
• US Class Current: 600/545
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia

Abstract

A method and apparatus for identifying and alleviating semantic memory deficiencies. An electroencephalogram signal is detected from the scalp of a subject to produce a signal representative of evoked response potentials. The subject is instructed to perform a semantic memory task in response to a stimulus. The amplitude of the most positive-going peak of the evoked response potential signal during the 270-550 ms period following the stimulus is measured. To determine whether the subject suffers from early Alzheimer'"'"'s disease, the amplitude of the signal is compared to a standard determined by applying the same method to normal subjects. The amplitude of the signal may also be used to provide a feedback signal to the subject for training the subject to improve the subject'"'"'s semantic memory skills. An apparatus is provided for implementing these steps using digital signal processing, and for providing a biofeedback signal to the subject.

Claims

1. An apparatus for training a subject to improve the subject'"'"'s ability to perform a semantic memory task, comprising:

(a) detection means for detecting the electroencephalogram signal from the scalp of said subject to produce a signal representative of evoked response potentials;

(b) display means for displaying symbols to a subject in a predetermined manner;

(c) input means for receiving from said subject a signal representative of whether said subject ascribes meanings to the symbol;

(d) measurement means for measuring the amplitude of the most positive-going peak of said evoked response potential signal during the 270-550 ms period following the display of a given signal; and

(e) feedback means for providing to said subject a signal indicative of said amplitude.

2. A method for training a subject to improve the subject'"'"'s ability to perform semantic memory tasks, comprising:

(a) detecting the electroencephalogram signal from the scalp of said subject to produce a signal representative of evoked response potentials;

(b) instructing the subject to perform a semantic memory task in response to a stimulus;

(c) measuring the amplitude of the most positive-going peak of said evoked response potential signal during the 270-550 ms period following said stimulus; and

(d) producing a signal perceptible by said subject indicative of said amplitude.

3. The method of claim 2, further comprising detecting an electromyogram signal representative of the general relaxation of said subject and producing a signal perceptible to said subject indicative of the degree of said subject'"'"'s relaxation.

4. The method of claim 3, further comprising not producing a signal indicative of said amplitude unless said electromyogram signal is less than a predetermined amount.

5. The method of claim 2, wherein said signal indicative of said amplitude is an audio signal whose characteristics are understood to be proportional to said amplitude.

6. The method of claim 2, wherein said signal indicative of said amplitude is a visual signal.

7. The method of claim 2, wherein said semantic memory task comprises observing a visual display of a sequence of symbols and determining whether the symbol has a predetermined meaning.

8. The method of claim 7, further comprising presenting to said subject said visual display of a sequence of symbols, said period being measured from the time of presentation of each such symbol.

9. The method of claim 8, wherein said sequence of symbols comprises a set of infrequently repeated symbols interspersed randomly among repetitions of a frequently repeated symbol.

10. The method of claim 2, wherein said semantic memory task comprises observing a visual display of a sequence of infrequently repeated names interspersed randomly among repetitions of a frequently repeated name and determining whether the names are male or female names.

11. The method of claim 10, further comprising actuating a switch means for producing a signal representative of whether the names are male or female names.