Method and apparatus for non-invasive monitoring of central venous pressure

• US 4,986,277 A
• Filed: 08/24/1988
• Issued: 01/22/1991
• Est. Priority Date: 08/24/1988
• Status: Expired due to Term

• Current Assignee: VivoMetrics, Inc.
• Original Assignee: Non-Invasive Monitoring Systems, Inc.
• Inventors: Sackner, Marvin A.
• Primary Examiner(s): LACYK, JOHN P
• Application Number:
  US07/235,672
• Time in Patent Office: 881 Days
• Field of Search: 128/670-674, 128/687-688, 128/691, 128/694, 128/713, 128/716, 128/721, 128/774, 128/748
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02152 specially adapted for venous pressure
• CPC Class Codes: A61B 5/1073 Measuring volume, e.g. of limbs
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis

Abstract

A method and apparatus for measuring central venous pressure (CVP) is disclosed, along with an improved transducer (50) for measuring CVP in infants. Changes in CVP may also be monitored by employing the method and apparatus of the invention. According to the invention, a transducer is disposed on the neck of a subject (or on the head in the case of infants), and the signal from the transducer is processed to obtain the cardiac component. Thereafter, the vertical distance from the transducer to a reference level is adjusted until the position is located at which the signal transitions between a venous configuration and an arterial or mixed venous-arterial configuration, at which position the vertical distance approximates CVP.

Claims

1. A method for measuring CVP comprising:

disposing a transducer on the neck of a subject;

processing the signal from the transducer to obtain the cardiac component; and

adjusting the vertical distance from the transducer to a reference level until a position is located at which the signal transitions between a venous configuration and an arterial or mixed venous-arterial configuration, at which position said vertical distance approximates CVP.

2. The method of claim 1, wherein said disposing step comprises disposing a neck inductive plethysmograph about the neck, said neck inductive plethysmograph including a conductive loop extending about the neck.

3. The method of claim 1, wherein said processing step comprises ensemble averaging.

4. The method of claim 1, wherein said processing step comprises high pass filtering.

5. The method of claim 1, wherein said processing step comprises matching the lower frequency respiration component with a mathematically derived curve fit, and then subtracting said curve fit from the transducer signal.

6. The method of claim 1, wherein said subject'"'"'s torso is substantially horizontal, and said adjusting step comprises moving the upper portion of the subject, at least including the head.

7. The method of claim 2, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising, before said processing step, the step of converting the variable frequency output of the oscillator to a variable voltage signal.

8. The method of claim 1, further comprising the step of disposing a second transducer about the neck above the first transducer in spaced relation therefrom, wherein said adjusting step comprises adjusting said vertical distance until the first transducer signal depicts said venous configuration and said second transducer signal depicts said arterial or mixed venous-arterial configuration, and further comprising the step of monitoring changes in CVP by evaluating whether said first transducer signal changes to an arterial or mixed venous-arterial configuration or said second transducer signal changes to a venous configuration.

9. The method of claim 8, wherein said evaluating step comprises providing an aural and/or visual alarm responsive to said changes.

10. The method of claim 8, wherein said disposing step comprises disposing first and second neck inductive plethysmographs about the neck, said neck inductive plethysmographs each including a conductive loop extending about the neck.

11. The method of claim 8, wherein said subject'"'"'s torso is substantially horizontal, and said adjusting step comprises moving the upper portion of the subject, at least including the head.

12. The method of claim 10, wherein each conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising, before said processing step, the step of converting the variable frequency output of the oscillator to a variable voltage signal.

13. A method for monitoring changes in CVP comprising:

disposing a transducer on the neck of a subject;

processing the signal from the transducer to obtain the cardiac component;

determining whether said signal initially depicts a (1) venous configuration or (2)arterial or mixed venous-arterial configuration; and

monitoring said signal for a change from its initially depicted configuration to the other configuration, said monitored change being indicative of a change in CVP.

14. The method of claim 13, wherein said disposing step comprises disposing a neck inductive plethysmograph about the neck, said neck inductive plethysmograph including a conductive loop extending about the neck.

15. The method of claim 14, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising, before said processing step, the step of converting the variable frequency output of the oscillator to a variable voltage signal.

16. The method of claim 13, wherein said processing step comprises ensemble averaging.

17. The method of claim 13, wherein said processing step comprises high pass filtering.

18. The method of claim 13, wherein said processing step comprises matching the lower frequency respiration component with a mathematically derived curve fit, and then subtracting said curve fit from the transducer signal.

19. The method of claim 13, further comprising the step of disposing a second transducer about the neck above the first transducer in spaced relation therefrom, further comprising adjusting the vertical distance from the first transducer to a reference level until the first transducer signal depicts said venous configuration and said second transducer signal depicts said arterial or mixed venous-arterial configuration, and wherein said monitoring step comprises evaluating whether said first transducer signal changes to an arterial or mixed venous-arterial configuration or said second transducer signal changes to a venous configuration.

20. The method of claim 19, wherein said monitoring step comprises providing an aural and/or visual alarm responsive to said changes.

21. The method of claim 19, wherein said disposing step comprises disposing first and second neck inductive plethysmographs about the neck, said neck inductive plethysmographs each including a conductive loop extending about the neck.

22. The method of claim 21, wherein each conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising, before said processing step, the step of converting the variable frequency output of the oscillator to a variable voltage signal.

23. The method of claim 19, wherein said subject'"'"'s torso is substantially horizontal, and said adjusting step comprises moving the upper portion of the subject, at least including the head.

24. The method of claim 13, wherein said subject'"'"'s torso is substantially horizontal.

25. A method for measuring CVP in infants comprising:

disposing a transducer on the head of an infant;

processing the signal from the transducer to obtain the cardiac component; and

adjusting the vertical distance from the transducer to a reference level until a position is located at which the signal transitions between a venous configuration and an arterial or mixed venous-arterial configuration, at which position said vertical distance approximates CVP.

26. The method of claim 25, wherein said disposing step comprises disposing an inductive plethysmograph about the head, said inductive plethysmograph including a conductive loop extending about the head.

27. The method of claim 26, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising, before said processing step, the step of converting the variable frequency output of the oscillator to a variable voltage signal.

28. The method of claim 25, wherein said processing step comprises ensemble averaging.

29. The method of claim 25, wherein said processing step comprises high pass filtering.

30. The method of claim 25, wherein said processing step comprises matching the lower frequency respiration component with a mathematically derived curve fit, and then subtracting said curve fit from the transducer signal.

31. The method of claim 25, wherein said infant'"'"'s torso is substantially horizontal, and said adjusting step comprises moving the upper portion of the infant, at least including the head.

32. A method for monitoring changes in CVP in infants comprising:

disposing a transducer on the head of an infant;

processing the signal from the transducer to obtain the cardiac component;

determining whether said signal initially depicts a (1) venous configuration or (2) arterial or mixed venous-arterial configuration; and

monitoring said signal for a change from its initially depicted configuration to the other configuration, said monitored change being indicative of a change in CVP.

33. The method of claim 32, wherein said disposing step comprises disposing an inductive plethysmograph about the head, said inductive plethysmograph including a conductive loop extending about the head.

34. The method of claim 33, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising, before said processing step, the step of converting the variable frequency output of the oscillator to a variable voltage signal.

35. The method of claim 32, wherein said processing step comprises ensemble averaging.

36. The method of claim 32, wherein said processing step comprises high pass filtering.

37. The method of claim 32, wherein said processing step comprises matching the lower frequency respiration component with a mathematically derived curve fit, and then subtracting said curve fit from the transducer signal.

38. The method of claim 32, wherein said monitoring step comprises providing an aural and/or visual alarm responsive to said change.

39. The method of claim 32, wherein said infant is near or in a horizontal plane.

40. An apparatus for measuring CVP comprising:

a transducer disposed on the neck of a subject;

means for processing the signal from the transducer to obtain the cardiac component; and

means for measuring the vertical distance from the transducer to a reference level after the neck is adjusted to a position at which the signal transitions between a venous configuration and an arterial or mixed venous-arterial configuration, said vertical distance approximating CVP.

41. The apparatus of claim 40, wherein said transducer comprises a neck inductive plethysmograph, said neck inductive plethysmograph including a conductive loop extending about the neck.

42. The apparatus of claim 41, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising means for converting the variable frequency output of the oscillator to a variable voltage signal.

43. The apparatus of claim 40, wherein said means for processing comprises means for ensemble averaging.

44. The apparatus of claim 40, wherein said processing means comprises means for high pass filtering.

45. The apparatus of claim 40, wherein said processing means comprises means for matching the lower frequency respiration component with a mathematically derived curve fit, and for then subtracting said curve fit from the transducer signal.

46. The apparatus of claim 40, wherein said subject'"'"'s torso is substantially horizontal, and further comprising means for moving the upper portion of the subject, at least including the heat, said moving means operating to adjust the position of the subject'"'"'s neck.

47. The apparatus of claim 40, further comprising a second transducer disposed about the neck above the first transducer in spaced relation therefrom, and wherein said neck is adjusted until the first transducer signal depicts said venous configuration and said second transducer signal depicts said arterial or mixed venous-arterial configuration, and further comprising means for determining whether said first transducer signal changes to an arterial or mixed venous-arterial configuration or said second transducer signal changes to a venous configuration.

48. The apparatus of claim 47, wherein said determining means further comprises means for providing an aural and/or visual alarm responsive to said changes.

49. The apparatus of claim 47, wherein said first and second transducers comprise first and second neck inductive plethysmographs disposed about the neck, said neck inductive plethysmographs each including a conductive loop extending about the neck.

50. The apparatus of claim 49, wherein each conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising means for converting the variable frequency output of the oscillator to a variable voltage signal.

51. The apparatus of claim 47, wherein said subject'"'"'s torso is substantially horizontal, and further comprising means for moving the upper portion of the subject, at least including the head, said moving means operating to adjust the position of the subject'"'"'s neck.

52. An apparatus for monitoring changes in CVP comprising:

transducer disposed on the neck of a subject;

means for processing the signal from the transducer to obtain the cardiac component;

means for determining whether said signal initially depicts a (1) venous configuration or (2) arterial or mixed venous-arterial configuration; and

means for monitoring said signal for a change from its initially depicted configuration to the other configuration and for indicating a change in CVP in response to a monitored change.

53. The apparatus of claim 52, wherein said transducer comprises a neck inductive plethysmograph disposed about the neck, said neck inductive plethysmograph including a conductive loop extending about the neck.

54. The apparatus of claim 53, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising means for converting the variable frequency output of the oscillator to a variable voltage signal.

55. The apparatus of claim 52, wherein said means for processing comprises means for ensemble averaging.

57. The apparatus of claim 52, wherein said means for processing comprises means for matching the lower frequency respiration component with a mathematically derived curve fit and means for then subtracting said curve fit from the transducer signal.

58. The apparatus of claim 52, further comprising a second transducer disposed about the neck above the first transducer in spaced relation therefrom with the vertical distance from the first transducer to a reference level adjusted until the first transducer signal depicts said venous configuration and said second transducer signal depicts said arterial or mixed venous-arterial configuration, and wherein said means for monitoring comprises means for evaluating whether said first transducer signal changes to an arterial or mixed venous-arterial configuration or said second transducer signal changes to a venous configuration.

59. The apparatus of claim 58, wherein said monitoring step further comprises for providing an aural and/or visual alarm responsive to said changes.

60. The apparatus of claim 58, wherein said first and second transducers comprise first and second neck inductive plethysmographs disposed about the neck, said neck inductive plethysmographs each including a conductive loop extending about the neck.

61. The apparatus of claim 60, wherein each conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising means for converting the variable frequency output of the oscillator to a variable voltage signal.

62. The apparatus of claim 58, wherein said subject'"'"'s torso is substantially horizontal, and further comprising means for moving the upper portion of the subject, at least including the head, for adjusting the vertical distance from the first transducer to said reference level.

56. The apparatus 52, wherein said means for processing comprises means for high pass filtering.

63. An apparatus for measuring CVP in infants comprising:

a transducer disposed on the head of an infant;

means for processing the signal from the transducer to obtain the cardiac component; and

means for measuring the vertical distance from the transducer to a reference level after a position is located at which the signal transitions between a venous configuration and an arterial or mixed venous-arterial configuration, at which position said vertical distance approximates CVP.

64. The apparatus of claim 63, wherein said transducer comprises an inductive plethysmograph disposed about the head, said inductive plethysmograph including a conductive loop extending about the head.

65. The apparatus of claim 64, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising means for converting the variable frequency output of the oscillator to a variable voltage signal.

66. The apparatus of claim 64, wherein said means for processing comprises means for ensemble averaging.

67. The apparatus of claim 64, wherein said means for processing comprises means for high pass filtering.

68. The apparatus of claim 64, wherein said means for processing comprises matching the lower frequency respiration component with a mathematically derived curve fit, and means for then subtracting said curve fit from the transducer signal.

69. The apparatus of claim 64, wherein said infant'"'"'s torso is substantially horizontal, and further comprising means for moving the upper portion of the infant, at least including the head, for locating the position of signal transition.

70. An apparatus for monitoring changes in CVP in infants comprising:

a transducer disposed on the head of an infant;

means for processing the signal from the transducer to obtain the cardiac component;

means for determining whether said signal initially depicts a (1) venous configuration or (2) arterial or mixed venous-arterial configuration; and

means for monitoring said signal for a change from its initially depicted configuration to the other configuration and for indicating a change in CVP in response to a monitored change.

71. The apparatus of claim 70, wherein said transducer comprises an inductive plethysmograph disposed about the head, said inductive plethysmograph including a conductive loop extending about the head.

72. The apparatus of claim 71, wherein said conductive loop is incorporated as the inductance element in an LC oscillator such that variations in the inductance of the loop are reflected as changes in the frequency of the oscillator, and further comprising means for converting the variable frequency output of the oscillator to a variable voltage signal.

73. The apparatus of claim 71, wherein said means for processing comprises means for ensemble averaging.

74. The apparatus of claim 71, wherein said means for processing comprises means for high pass filtering.

75. The apparatus of claim 71, wherein said means for processing comprises means for matching the lower frequency respiration component with a mathematically derived curve fit, and means for then subtracting said curve fit from the transducer signal.

76. The apparatus method of claim 71, wherein said means for monitoring comprises means for providing an aural and/or visual alarm responsive to said change.