Method and apparatus for identifying and alleviating semantic memory deficiencies

• US 4,987,903 A
• Filed: 11/14/1988
• Issued: 01/29/1991
• Est. Priority Date: 11/14/1988
• Status: Expired due to Term

• Current Assignee: William Keppel
• Original Assignee: Kenneth R. Erickson, William Keppel
• Inventors: Erickson, Kenneth R., Keppel, William
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Schaetzle, Kennedy J.
• Application Number:
  US07/271,164
• Time in Patent Office: 806 Days
• Field of Search: 128/731, 128/732, 128/733, 128/745, 364/413.02
• US Class Current: 600/545
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia

Abstract

A method and apparatus for identifying and alleviating semantic memory deficiencies. An electroencephalogram signal is detected from the scalp of a subject to produce a signal representative of evoked response potentials. The subject is instructed to perform a semantic memory task in response to a stimulus. The amplitude of the most positive-going peak of the evoked response potential signal during the 270-550 ms period following the stimulus is measured. To determine whether the subject suffers from early Alzheimer'"'"'s disease, the amplitude of the signal is compared to a standard determined by applying the same method to normal subjects. The amplitude of the signal may also be used to provide a feedback signal to the subject for training the subject to improve the subject'"'"'s semantic memory skills. An apparatus is provided for implementing these steps using digital signal processing, and for providing a biofeedback signal to the subject.

Claims

1. A method for diagnosing Alzheimer'"'"'s disease, comprising:

(a) detecting the electroencephalogram signal from the scalp of a subject to produce a signal representative of evoked response potentials;

(b) instructing the subject to perform a semantic memory task in response to a stimulus;

(c) measuring the amplitude of the most positive-going peak of said evoked response potential signal during the 270-550 ms period following said stimulus; and

(d) comparing said amplitude to a standard to determine whether said amplitude indicates an Alzheimer'"'"'s disease condition.

2. The method of claim 1, wherein said semantic memory task comprises observing a visual display of a sequence of symbols, and taking some action to indicate that the subject ascribes a predetermined meaning to a given symbol, where that is so.

3. The method of claim 2, wherein said sequence of symbols comprises a set of infrequently repeated names interspersed randomly among repetitions of a frequently repeated name.

4. The method of claim 3, wherein said action comprises actuating a switch means for producing a signal representative of whether the subject ascribes a male meaning or a female meaning to an observed name.

5. The method of claim 2, further comprising presenting to said subject said visual display of a sequence of symbols, said period being measured from the time of presentation of each such symbol.

6. The method of claim 5, wherein said sequence of symbols comprises a set of infrequently repeated symbols interspersed randomly among repetitions of a frequently repeated symbol.

7. The method of claim 5, wherein said measuring step includes averaging the amplitude of said evoked response potential for each infrequently repeated symbol to produce a first average, averaging said evoked response potential for the frequently repeated symbol to produce a second average, and subtracting said second average from said first average to produce resultant data.

8. The method of claim 7, wherein said maximum positive-going peak is measured by computing the difference between the amplitude of the maximum positive-going peak of said resultant data during the 270-550 ms period following said stimulus and the amplitude of the maximum negative-going peak of said resultant data during the 150-270 ms period following said stimulus.

9. The method of claim 1, wherein said standard is the amplitude of the maximum positive peak for a set of subjects who do not have Alzheimer'"'"'s disease.

10. The method of claim 1, wherein said comparing step is performed by digitizing said evoked response potential signals and analyzing the digital representation of those waveforms.

11. An apparatus for diagnosing Alzheimer'"'"'s disease, comprising:

(a) detection means for detecting the electroencephalogram signal from the scalp of a subject to produce a signal representative of evoked response potentials;

(b) display means for displaying symbols to a subject in a predetermined manner;

(c) input means for receiving from the subject a signal representative of whether the subject ascribes meaning to a given symbol; and

(d) measurement means for measuring the amplitude of the most positive peak of said evoked response potential signal during the 270-550 ms period following the display of a given symbol.

12. The apparatus of claim 11, wherein said measurement means comprises digitizer means for receiving said evoked response potentials from said detection means and producing a digital representation thereof, and digital computer means for operating on said digital representation to determine said amplitude.

13. The apparatus of claim 12, wherein said display means includes means for presenting to said subject a sequence of symbols comprising a set of infrequently repeated names interspersed randomly among repetitions of a frequently repeated name.

14. The apparatus of claim 13, wherein said digital computer means is programmed to average the amplitudes of said evoked response potential for infrequently repeated symbols to produce a first average, average the amplitude of said evoked response potentials for the frequently repeated symbols to produce a second average, and subtract said second average from said first average to produce resultant data.

15. The apparatus of claim 14, wherein said digital computer means is programmed to subtract the amplitude of the maximum negative-going peak of said resultant data during the 150-270 ms period following said stimulus from the amplitude of the maximum positive-going peak of said resultant data during the 270-550 ms period following said stimulus.

16. The apparatus of claim 12, wherein said digital computer means is programmed to compare the amplitude of said most positive-going peak to a standard amplitude and provide the difference therebetween.