Method for promoting hard tissue growth and repair in mammals
First Claim
1. A method for promoting hard tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of material with a deliberately produced chemically induced effective surface charge to said sites, the tissue site being bone and the deficit being caused by at least one of trauma, non-union fracture, malignancy and malformation in said bone and said charge material being applied to said site and said material being an ion exchange material having a negative charge, said effective quantity being sufficient to promote said growth and repair.
0 Assignments
0 Petitions
Accused Products
Abstract
A material with chemically induced surface charges is employed to foster formation of mammalian hard and soft connective tissues. The material may be in the form of beads such as ion exchange resins. Bead materials with a negative surface charge stimulate formation of hard tissue within long bones and foster bony repair of defects in parietal bones and in mandibular rami. Beads with positively charged surfaces engender formation of large quantities of soft dense connective tissue when implanted into defects in the cranium or when used as an onlay on the nasal bone surface. The use of such beads or other charged biodegradable materials and the use of other surface charged materials with different physical configurations provides significant improvement in hard and soft connective tissue repair, augmentation and replacement in medical fields such as orthopaedic and maxillofacial surgery.
71 Citations
9 Claims
- 1. A method for promoting hard tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of material with a deliberately produced chemically induced effective surface charge to said sites, the tissue site being bone and the deficit being caused by at least one of trauma, non-union fracture, malignancy and malformation in said bone and said charge material being applied to said site and said material being an ion exchange material having a negative charge, said effective quantity being sufficient to promote said growth and repair.
- 7. A method for promoting hard tissue growth annd repair in site of tissue defects in living mammals which comprises applying an effective quantity of material with a deliberately produced chemically induced effective surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being bone and the deficit being caused by at least one of trauma, non-union fracture, malignancy and malformation in said bone and said charge material being applied to said site, said material having a negative charge and said material being applied in the form of small discrete spherical beads, said beads being a biodegradable ion exchange material and comprised of a dextran matrix having functional groups.
-
9. A method for promotingg hard tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of material with a deliberately produced chemically induced affecttive surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being bone and the deficit being caused by at least one of trauma, non-union fracture, malignancy and malformation in said bone and said charge material being applied to said site, said material having a negative charge and said material being applied in the form of small discrete spherical beads, said beads being an ion exchange material and comprised of a dextran matrix having functional groups.
Specification