Tricyclic quinolizine amides
First Claim
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1. A compound of the formula ##STR12## the pharmaceutically acceptable salts thereof, and the hydrated forms thereof, wherein R1 and R2 are independently alkyl of from 1 to 10 carbon atoms;
- R3 is hydrogen in either a cis or a trans orientation; and
R4 is NHCOR'"'"' in either a cis or a trans orientation, wherein R'"'"' is alkyl of from 1 to 10 carbon atoms, cycloalkyl of from 3 to 8 carbon atoms, phenyl, phenyl substituted by alkyl of one to ten carbon atoms or alkoxy of from one to ten carbon atoms, halogen, or amino, fused phenylcycloalkyl, fused phenylcycloalkyl wherein phenyl is substituted by alkyl of from one to ten carbon atoms, benzofuranyl or benzofuranyl substituted by alkyl of from one to ten carbon atoms.
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Abstract
Tricyclic quinolizine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.
22 Citations
31 Claims
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1. A compound of the formula ##STR12## the pharmaceutically acceptable salts thereof, and the hydrated forms thereof, wherein R1 and R2 are independently alkyl of from 1 to 10 carbon atoms;
- R3 is hydrogen in either a cis or a trans orientation; and
R4 is NHCOR'"'"' in either a cis or a trans orientation, wherein R'"'"' is alkyl of from 1 to 10 carbon atoms, cycloalkyl of from 3 to 8 carbon atoms, phenyl, phenyl substituted by alkyl of one to ten carbon atoms or alkoxy of from one to ten carbon atoms, halogen, or amino, fused phenylcycloalkyl, fused phenylcycloalkyl wherein phenyl is substituted by alkyl of from one to ten carbon atoms, benzofuranyl or benzofuranyl substituted by alkyl of from one to ten carbon atoms. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
- R3 is hydrogen in either a cis or a trans orientation; and
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2. A compound of the general formula ##STR13## and or the pharmaoeutically acceptable salts thereof, wherein R1 and R2 are independently alkyl of from 1 to 10 carbon atoms;
- R3 is hydrogen in either the cis or trans orientation; and
R4 is NCHOR'"'"' in either the cis or trans orientation, wherein R'"'"' is alkyl of from 1 to 10 carbon atoms, cyclohexyl, phenyl, phenyl substituted by alkoxy of from one to ten carbon atoms, halogen or amino, fused phenylcyclohexyl, or benzofuranyl. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- R3 is hydrogen in either the cis or trans orientation; and
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Current AssigneeGD Searle LLC (Pfizer Inc.)
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Original AssigneeGD Searle LLC (Pfizer Inc.)
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InventorsFowler, Kerry W.
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Primary Examiner(s)TSANG, CECILIA J
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Application NumberUS07/402,955Time in Patent Office525 DaysField of Search546/95, 514/294US Class Current514/294CPC Class CodesA61P 9/06 AntiarrhythmicsC07D 455/04 containing a quinolizine ri...
