Apparatus and method for collecting and freezing blood plasma

• US 4,994,021 A
• Filed: 11/15/1988
• Issued: 02/19/1991
• Est. Priority Date: 11/15/1988
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Smith, Sidney T., Glash, Dean M.
• Primary Examiner(s): Rosebaum, C. Fred
• Assistant Examiner(s): Maglione, Corrine
• Application Number:
  US07/271,471
• Time in Patent Office: 826 Days
• Field of Search: 604/6, 604/262, 604/408-410, 128/DIG. 24
• US Class Current: 604/6.04
• CPC Class Codes: A61M 1/0236 with sampling means, e.g. sample bag or sampling port
• CPC Class Codes: A61M 1/0277 Frames constraining or supporting bags, e.g. during freezing
• CPC Class Codes: F25C 1/22 Construction of moulds; Filling devices for moulds

Abstract

Disclosed is an improved apparatus and method for collecting, freezing and removing a liquid such as blood or blood components, and particularly blood plasma. In accordance with the present invention, a container (16) for blood plasma is defined by a pair of substantially flat, flexible opposing sidewalls (40, 42) which are substantially adjacent when the container is empty. The sidewalls are peripherally sealed together to define an interior compartment, and the side seals (44, 46) converge toward one end (48) of the container. After a selected quantity of plasma is collected in the container, the filled container is formed and frozen in a wedge-shaped configuration, with the opposed sidewalls (40,42) converging toward the end of the container. An air space (82) may be provided in the top of the container so that a knife (86) may be easily inserted into the frozen container without contacting the frozen liquid (88) therein. Slight warming of the container then permits the frozen contents to be removed efficiently as a single slug. Also disclosed is a form (60) for shaping a container as described above into a wedge-shape for freezing. The form includes a pair of rigid, perforated walls (62, 66) hinged together at one end (64) and configured to receive a container therebetween. The rigid walls of the form are disposed to shape the container walls into a converging configuration during freezing.

Claims

1. A container having a frozen plasma slug therein, comprising:

a pair of sidewalls made from polyvinyl chloride material, peripherally sealed together to define an interior compartment;

means for accessing the interior compartment;

said sidewalls converging toward one end of said container to form a generally wedge-shape;

a quantity of frozen plasma within said container;

wherein said container of frozen plasma is formed by providing a container of flexible opposing sidewalls having an empty lay-flat configuration, collecting a quantity of liquid plasma in said container, inserting the liquid plasma-containing container into a form that defines a V-shape about the container, engaging the sidewalls of the plasma-containing counter with the form so as to press the sidewalls into a V-shape, so that said sidewalls converge toward one end of the container, and freezing the plasma-containing container while maintaining the container in said V-shaped configuration in the form, thereby forming a wedge-shaped container having a frozen, wedge-shaped plasma slug therein.

2. A container in accordance with claim 1 wherein said quantity of frozen liquid is of a selected volume so that a portion of the interior compartment between the frozen liquid and the other end remains unfilled.

3. A container in accordance with claim 1 wherein said sidewalls converge continuously toward said one end when said container is filled with said frozen liquid.

4. A container in accordance with claim 1 wherein said sidewalls are rigid when said container is filled with said frozen liquid.

5. A container in accordance with claim 1 wherein said side seals converge toward said one end of said container.

6. A container in accordance with claim 1 wherein said means for accessing said interior compartment further comprises at least one tubular inlet at the other end.

7. A container in accordance with claim 6 further comprising flexible tubing communicating with said tubular inlet.

8. A container in accordance with claim 1 wherein said plasma is substantially free of platelets.

9. A method for collecting and freezing plasma comprising:

providing a container comprising a pair of substantially flat flexible opposing plastic sidewalls, which sidewalls are substantially adjacent when the container is in an unfilled condition so as to provide an empty lay-flat configuration;

said sidewalls being peripherally sealed together to define an interior compartment; and

means for accessing said interior compartment;

collecting a quantity of liquid plasma in said container, said liquid plasma resulting in a generally bulbous shape in the sidewalls of the container;

inserting the liquid plasma-containing container into a form that defines a V-shape about the container;

engaging the sidewalls of the plasma-containing container with the form so as to press the sidewalls into a V-shape, so that said sidewalls converge toward one end of the container; and

freezing the plasma-containing container while maintaining the container in said V-shaped configuration in the form, thereby forming a wedge-shaped container having a frozen, wedge-shaped plasma slug therein.

10. A method in accordance with claim 9 further comprising the step of placing the wedge-shaped container in a freezer.

11. A method in accordance with claim 9 further comprising thawing the outer layer of said frozen liquid.

12. A method in accordance with claim 9 wherein method further comprises removing the other end of said container.

13. A method in accordance with claim 12 wherein method further comprises expelling said frozen liquid out said cut end.

14. A method in accordance with claim 12 wherein said removing step comprises cutting said other end of said container without contacting the frozen liquid.

15. A form for shaping a container of liquid plasma having flexible walls, wherein the container when empty has a generally lay-flat configuration, into a generally wedge-shaped container with a frozen, generally wedge-shaped plasma slug therein, which form comprises:

a pair of thermally-conductive rigid walls hinged together at one end;

at least one of said rigid walls defining perforation holes to promote cold air circulation and freezing;

said walls being relatively pivotal between a first position in which the walls are spaced sufficiently far apart to receive at least one container therebetween, and a second position sufficiently close together to engage the flexible walls of the container; and

means for holding said rigid walls in said second position;

said rigid walls of said form being disposed to shape the container walls into a converging configuration when moved to said second position.

16. A form in accordance with claim 15 further comprising means for hanging said form.

17. A form in accordance with claim 16 wherein said hanging means comprises oppositely extending rods.

18. A form in accordance with claim 15 wherein said holding means comprises a latch for holding said rigid walls in said second position.