Electrochemical drug release and article

• US 4,994,023 A
• Filed: 08/08/1989
• Issued: 02/19/1991
• Est. Priority Date: 08/08/1989
• Status: Expired due to Fees

• Current Assignee: Southwest Research Institute
• Original Assignee: Southwest Research Institute
• Inventors: Wellinghoff, Stephen T., Baker, Charles K.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Rose, Sharon
• Application Number:
  US07/391,282
• Time in Patent Office: 560 Days
• Field of Search: 604/891.1, 604/20, 128/802, 128/803, 128/639, 128/640, 128/642
• US Class Current: 604/20
• CPC Class Codes: A61K 47/58 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

An electrochemical drug release article containing an electrically conducting self-doped carbazole polymer of the formula: ##STR1## wherein A is a bifunctional molecule capable of bonding to a positively charged molecule at one end and is capable of bonding to a flexible spacer group Z at another end, Z is a flexible spacer group capable of bonding to an anionic group A at one end and is capable of bonding either to a nitrogen or aromatic electron withdrawing or electron donating group at another end, E is a bifunctional molecule capable of bonding to nitrogen at one end and is capable of bonding to a flexible spacer group Z at another end, X is a positively charged counterion, and n is at least 2.

Claims

1. A drug delivery device comprising an electrically conducting self-doped carbozole polymer of the formula:

##STR4## wherein A is a bifunctional molecule capable of bonding to a positively charged molecule at one end and is capable of bonding to a flexible spacer group Z at another end, Z is a flexible spacer group capable of bonding to an anionic group A at one end and is capable of bonding to either to an aromatic nitrogen or electron withdrawing or electron donating group at another end, E is a bifunctional molecule capable of bonding to nitrogen at one end and is capable of bonding to a flexible spacer group Z at another end, X is a positively charged drug molecule, and n is at least 2, in the form of a film embedded in an electrolyte, a cathode and an anode operatively associated, respectively, with said polymer film and said electrolyte, and a source of electrical power operatively associated with said cathode and anode.

2. The device of claim 1 wherein the electrolyte is a biodegradable gel and said film is water-soluble.

3. The device of claim 1 or 2 wherein said source of electrical power is a battery.

4. The device of claim 1 wherein X is a cationic drug.

5. The device of claim 1 wherein A is a sulfonate or carboxylate, Z is a (--CH₂ --)_n group with n equal to at least 1or a (--ROR--) group with R being a C₁ to C₄ alkylene group, E is a furan, pyrrole, thiophene, pyrimidine, or vinyl benzene group, and n is 2 to 100.

6. The drug of claim 1 or 5 wherein x is a hydrochloride of cocaine, cocaine derivative, barbituate, phenothiazene, atipyrine, morphine, codeine, analeptic, adrenergic blocker, cholinergic blocker, or tertiary ammonium salt of an anticholinergic.