Apparatus and method for patients from a single donor or a restricted group of donors

• US 4,994,039 A
• Filed: 02/06/1987
• Issued: 02/19/1991
• Est. Priority Date: 11/15/1985
• Status: Expired due to Fees

• Current Assignee: Philip D. Mattson
• Original Assignee: Philip D. Mattson
• Inventors: Mattson, Philip D.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US07/013,220
• Time in Patent Office: 1,474 Days
• Field of Search: 604/408, 604/409, 604/410, 604/52
• US Class Current: 604/408
• CPC Class Codes: A61M 1/0209 Multiple bag systems for separating or storing blood components

Abstract

An apparatus for collecting, storing and providing multiple transfusions of blood in small quantities to premature infants from a single donor or a limited number of donors without wasting or discarding unused blood of such donor or donors, including a primary reservoir for collecting and storing a predetermined amount of blood from a donor, which amount is substantially less than is usually collected for adult transfusions. The apparatus is provided with a plurality of sterile, deformable satellite administering reservoirs for receiving blood from the primary reservoir in an amount corresponding to the need of the premature child. Each of the satellite reservoirs is provided with graduations thereon so that the amount of blood required by the premature infant can be collected and measured therein for subsequent transfusion to the infant. A method of providing a prolonged, continuous supply of blood for infusion to a premature infant from a single donor or a restricted number of donors is also disclosed. A first predetermined quantity of blood is collected from the donor and is stored in a sterile primary reservoir. A second and subsequent predetermined amounts of blood, corresponding to the infusion needs of the infant are withdrawn from the sterile primary reservoir into an isolated secondary reservoir without adversely affecting the remainder of the blood in the primary reservoir. The blood from the secondary reservoirs is then administered to the infant.

Claims

1. A donor exposure limiting apparatus for providing multiple transfusions of blood to premature infants comprising:

a sterile, deformable primary reservoir having an inlet for admitting a first predetermined quantity of blood being substantially less than an adult-size donation of about 450 ml to about 550 ml from the donor into said primary reservoir;

collecting means for collecting said first predetermined quantity of blood from the donor and for conducting the blood to said inlet;

sterilely sealable outlets for releasing blood from said primary reservoir;

selectively releasable closures for preventing the release of blood from said reservoir through said outlets;

a plurality of sterile, deformable satellite administering reservoirs for receiving a second predetermined quantity of blood substantially corresponding to the infusion requirements of the premature infant from said primary reservoir and providing said second quantity to the infant, each of said satellite reservoirs having inlet means for selectively receiving said second predetermined quantity of blood from said primary reservoir, each of said satellite reservoirs having graduations thereon for visually indicating said second quantity received by said satellite reservoirs and outlet means for administering said second predetermined quantity of blood therefrom to the infant, at least one of said satellite reservoirs having top outlet means for releasing blood plasma, bottom outlet means for releasing red blood cells and a central portion between said top and bottom outlet means for containing white blood cells, whereby the blood plasma and the red blood cells are separable from the white blood cells in said at least one satellite reservoir

said primary reservoir having a capacity of about 150 ml and each of said satellite reservoirs having a capacity of about 40 ml, said first predetermined quantity being about 150 ml and said second preselected quantity being from about 10 ml to about 30 ml.

2. The apparatus as claimed in claim 1 further comprising sterile flow paths between said primary reservoir and each said satellite reservoir, each of said satellite reservoirs being adapted for sterile isolation from said primary reservoir after receipt of said second predetermined quantity of blood, said flow paths being adapted for sterile severing upon receipt of said second quantity of blood from said primary reservoir by any of said satellite reservoirs.

3. The apparatus as claimed in claim 2 in which each of said satellite reservoirs comprises flexible inert material being sufficiently durable to withstand centrifugation and/or irradiation with said second quantity of blood contained therein and being sufficiently flexible to permit aspiration of the blood without the injection of air into said satellite reservoir.

4. The apparatus as claimed in claim 1 in which said second predetermined quantity is an aliquot of said first quantity.

5. The apparatus as claimed in claim 2 further comprising a secondary reservoir bag being constructed similarly to said primary bag, said secondary reservoir including sterilely severable tubing for providing fluid-path communication between said primary reservoir and said secondary reservoir.

6. The apparatus as claimed in claim 1 in which said primary reservoir and said plurality of satellite administering reservoirs are isolated before receipt of said second quantity of blood by any of said satellite reservoirs, said primary reservoir further comprising pigtails and each of said satellite reservoirs further comprising corresponding pigtails communicatively connecting to said pigtails of said primary reservoir for permitting passage of said second quantity of blood from said primary reservoir to any of said secondary reservoirs.

7. The apparatus as claimed in claim 6 in which said communicatively connecting pigtails are further adapted for sterile separation after reception by said satellite reservoirs of said second quantity of blood.

8. The apparatus as claimed in claim 7 in which each of said satellite reservoirs comprises flexible nonreactant material being sufficiently durable to withstand centrifugation and/or irradiation with said second quantity of blood contained therein and being sufficiently flexible to permit aspiration of the blood without the injection of air into said satellite reservoir.

9. The apparatus as claimed in claim 6 further comprising mini-bag means for selectively receiving a third predetermined quantity of blood from said primary reservoir, said mini-bag means including pigtails, corresponding to said pigtails extending from said primary reservoir, for communicatively connecting said mini-bag means to said primary reservoir.

10. The apparatus as claimed in claim 9 in which said third predetermined quantity is less than said first preselected quantity and greater than said second predetermined quantity.

11. A method of providing a prolonged continuous supply of blood, for infusion to a premature infant, from a single donor or small group of donors, said donor and said donors in said small group of donors being capable of donating a first normal, adult-size donation of about 450 to about 550 ml of blood and being capable of subsequently donating a second normal, adult-size donation after a predetermined period, said method comprising the steps of:

(A) collecting a first predetermined quantity of blood, being substantially less than the normal, adult-size donation quantity, from said single donor or from one donor from said small group of donors, said first quantity being a fraction of the normal, adult-size donation;

(B) nondegeneratively storing said first collected quantity of blood in a primary reservoir, whereby said first quantity of blood has a normal, useful life;

(C) withdrawing a second predetermined quantity of blood, substantially corresponding to the infusion needs of the infant, from said primary reservoir into an isolated satellite reservoir without adversely affecting the blood remaining in said primary reservoir, whereby said remaining blood is depleted by an amount equal to said second quantity;

(D) administering said second quantity of blood to the infant from said satellite reservoir;

(E) recalling said donor or one of said donors from said small group of donors when the useful life of said remaining blood has expired or when said remaining blood is depleted to less than an amount equal to said second predetermined quantity;

(F) collecting another first predetermined quantity of blood from said donor or from one of said donors from said small group of donors within a period substantially less than said predetermined period between normal, adult-size donations;

(G) repeating steps (B) through (F) until the infant no longer requires infusions of blood.

12. The method as claimed in claim 11 in which said second quantity is less than said first quantity.

13. The method as claimed in claim 12 in which said first quantity is about 150 ml and said second quantity is from about 10 ml to about 30 ml.

14. The method as claimed in claim 13 further comprising the step of centrifuging said second quantity of blood in said satellite reservoir before administration to the infant.

15. The method as claimed in claim 14 further comprising the steps of removing a desired quantity of concentrated red blood cells by means of a bottom outlet in said satellite reservoir, removing a desired quantity of plasma by means of a top outlet in said satellite reservoir and remixing the red cells and the plasma for administration to the infant without need of subsequent weighing or estimating of the quantities of red cells and plasma in said mixture.

16. The method as claimed in claim 15 in which the plasma, white blood cells and the red blood cells define easily observable layers within said satellite reservoirs.

17. The method as claimed in claim 13 further comprising the step of irradiating said second quantity of blood in said satellite reservoir before administration to the infant.

18. The method as claimed in claim 12 in which an emergency quantity of blood equalling said second quantity is withdrawn to one of said satellite reservoirs and retained for emergency purposes.