Method for locating on a cornea an artificial lens fabricated from a collagen-hydrogel for promoting epithelial cell growth

• US 4,994,081 A
• Filed: 04/16/1990
• Issued: 02/19/1991
• Est. Priority Date: 10/16/1986
• Status: Expired due to Term

• Current Assignee: Cbs Lens
• Original Assignee: Cbs Lens
• Inventors: Civerchia, Linda, Shepard, Dennis D.
• Primary Examiner(s): Frinks, Ronald
• Application Number:
  US07/511,847
• Time in Patent Office: 309 Days
• Field of Search: 623/4-6, 128/1 R, 128/305, 128/334 R, 606/107, 606/166, 351/160 R, 351/160 H
• US Class Current: 606/107
• CPC Class Codes: A61F 2/142 Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
• CPC Class Codes: A61F 2/145 Corneal inlays, onlays, or lenses for refractive correction
• CPC Class Codes: A61F 2/15 Implant having one or more holes, e.g. for nutrient transport, for facilitating handling
• CPC Class Codes: A61F 2/1602 Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
• CPC Class Codes: A61F 2/1605 Anterior chamber lenses for use in addition to the natural lenses of the eyes, e.g. iris fixated, iris floating
• CPC Class Codes: A61F 2310/00005 The prosthesis being constructed from a particular material
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61F 9/00 Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand caps with means for protecting the eyes A42B1/018; visors for helmets A42B3/22; retractors A61B17/02; manipulators specially adapted for use in surgery A61B34/70; appliances to aid invalids to move about A61H3/00; exercisers for the eyes A61H5/00; eye baths A61H35/02; sunglasses or goggles having the same features as spectacles G02C
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: Y10S 623/906 Corneal

Abstract

A method for locating on the cornea an optical lens having a preselected geometric shape and power wherein the optical lens is formed of a collagen-hydrogel for promoting epithelial cell growth is shown. The method comprises the steps of: removing from Bowman'"'"'s membrane over the area of the pupillary zone of the eye a portion of the corneal epithelium; forming on Bowman'"'"'s membrane a "V" shaped annular groove having a diameter substantially equal to the maximum geometrical dimensions of the optical lens and a preselected depth; dissecting the peripheral edge of the groove forming a wing of corneal tissue having a preselected length; placing the posterior surface of the optical lens on the anterior surface of Bowman'"'"'s membrane and positioning the outer edge of the optical lens under the corneal wing, and affixing the optical lens to Bowman'"'"'s membrane over the pupillary zone of the eye to maintain the same on the cornea with the corneal wing overlying the edge of the optical lens. With the edge of the lens in contact with corneal epithelim, the collagen-hydrogel for promoting epithelial cell growth interacts with epithelial cells during a healing period to promote growth thereof over, and attach to, the anterior surface of the optical lens implanting the same under corneal epithelium.

Claims

1. A method for locating on the cornea an optical lens having a preselected geometric shape and power, said optical lens comprising an optical portion having an outer edge, a posterior surface and an anterior surface, said optical lens being formed of a hydrogel polymer formed by the free radical polymerization of a hydrophilic monomer solution gelled and crosslinked to form a three dimensional polymeric meshwork for anchoring collagen;

and a stock solution of collagen added to and interdisposed within said polymeric meshwork forming a collagen-hydrogel for promoting epithelial cell growth comprising the steps of;

removing from Bowman'"'"'s membrane over the pupillary zone of the eye a portion of corneal epithelium on an area slightly greater than the generalized shape of said optical lens;

forming on Bowman'"'"'s membrane a "v" shaped annular groove having a diameter substantially equal to the maximum geometrical dimensions of said optical lens and defining therearound a peripheral edge and medial edge and having a preselected depth which is less than the thickness of the corneal stroma;

dissecting the peripheral edge of said groove forming a wing of corneal tissue having a preselected length;

placing the posterior surface of said optical lens on the anterior surface of Bowman'"'"'s membrane and positioning the outer edge of said optical lens under said corneal wing, whereby the corneal wing lies flush with and in contact with the anterior surface of said lens; and

affixing the optical lens to the Bowman'"'"'s membrane over the pupillary zone of the eye to maintain the same on the cornea with the posterior surface in contact with Bowman'"'"'s membrane and the corneal wing overlying the edge of said optical lens enabling corneal epithelium to touch and interact with said optical lens formed of a stock solution of collagen added to a hydrogel polymer for promoting epithelial cell growth and adherence to said optical lens and to respond to the epithelial cells growth promoting constituent in said optical lens formed of a stock solution of collagen added to a hydrogel polymer over a healing period wherein epithelial cells grow in from the edge of said optical lens and over the same enabling the epithelial cells to adhere to and implant said optical lens in the cornea under a new growth of corneal epithelium formed from several layers of epithelial cells adhering to the optical lens.

2. The method claim of claim 1 wherein the predetermined depth of the "V" shaped annular groove is surgically formed to be about 0.3 mm and the predetermined length of the corneal wing is surgically formed to be about 1.5 mm.

3. The method of claim 1 wherein said optical lens includes an outer edge and wherein said steps of affixing the optical lens to the cornea comprises the step of

suturing the optical lens to said Bowman'"'"'s Membrane.

4. The method of claim 3 wherein the step of suturing includes the use of biodegradable sutures.

5. The method of claim 3 wherein the step of suturing includes the use of non biodegradable sutures.

6. The method of claim 1 wherein said step of affixing the optical lens to the cornea comprises the step of

bonding with a biodegradable adhesive the posterior surface of the optical lens to Bowman'"'"'s membrane.

7. The method of claim 1 wherein the step of affixing the optical lens to the cornea includes the step of

suturing the optical lens to said Bowman'"'"'s membrane with a biodegradable suturing material in the form of a "running shoe lace" stitching which passes through the outer edge of said optical lens and said Bowman'"'"'s membrane.

8. The method of claim 1 wherein the step of affixing the optical lens to the cornea includes the step of

suturing the optical lens to said Bowman'"'"'s membrane with a biodegradable suturing method in the form of an interrupted stitching which passes through the outer edge of said optical lens and said Bowman'"'"'s membrane.

9. The method of claim 1 wherein the step of affixing lens to the cornea includes the step of

holding the lens in place under the corneal wing with a bandage or a therapeutic contact lens until the epithelium grows over the collagen hydrogel.

10. The method of claim 1 further comprising the steps of:

severing the medial edge from the curved surface of the Bowman'"'"'s membrane.