Method and apparatus for determining a rate of flow of blood for an extracorporeal blood therapy instrument

• US 4,995,268 A
• Filed: 09/01/1989
• Issued: 02/26/1991
• Est. Priority Date: 09/01/1989
• Status: Expired due to Fees

• Current Assignee: ASH Medical Systems Incorporated
• Original Assignee: ASH Medical Systems Incorporated
• Inventors: Echard, Terrance G., Ash, Stephen R.
• Primary Examiner(s): Goldstein, Herbert
• Application Number:
  US07/402,073
• Time in Patent Office: 543 Days
• Field of Search: 73/198, 73/861.05, 210/647, 210/87, 210/743, 604/4, 604/65, 604/67
• US Class Current: 73/861.05
• CPC Class Codes: A61M 1/3431 upstream of the filter
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 Mode of operation
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621
• CPC Class Codes: G01F 1/7086 using optical detecting arrangements

Abstract

Method and apparatus for determining the flow rate of blood passing between a patient and an extracorporeal therapy instrument. The flow measurement apparatus includes a delivery unit for producing a saline bolus interface at a first position of a measurement channel having a predetermined volume between the first and second position. A sensor unit included in the apparatus detects the saline bolus interface as it passes the second position in the channel. An output signal from the sensor unit along with an indication of the production of the saline bolus interface is utilized by a control unit to determine the blood flow rate. The control unit of the apparatus utilizes instantaneous and average blood flow algorithms to calculate instantaneous and average blood flow rates based on the time interval associated with the production of the saline bolus interface and its progression to a predetermined position in the measurement channel. Successive interfaces are also produced in the blood flow to derive an average blood flow rate.

Claims

1. For use with an extracorporeal blood therapy instrument, apparatus for determining a rate of flow of blood through a channel, comprising:

delivery means for producing a trailing interface of another fluid and between said blood and said another fluid at a first predetermined position in said channel;

sensor means for producing an output signal indicative of when said trailing interface is at a second predetermined position in said channel, said channel having a predetermined volume between said first and second predetermined positions; and

control means utilizing a predetermined algorithm and an indication of said volume and responsive to said output signal and an indication of when said trailing interface is produced for calculating said blood flow rate through said channel.

2. The apparatus of claim 1 wherein said delivery means includes clamp means under control of said control means for selectively administering a bolus of said other fluid into said blood for producing said trailing interface.

3. The apparatus of claim 1 wherein said delivery means includes first means for transporting said blood, second means for transporting said other fluid, and connector means for inserting a bolus of said other fluid into said blood for producing said trailing interface.

4. The apparatus of claim 3 wherein said delivery means further includes clamp means under control of said control means for selectively occluding said flow of said blood and a flow of said other fluid in said first and second means, respectively.

5. The apparatus of claim 4 wherein said clamp means includes a clamping cavity and electric metor means under control of said control means for operating roller means in said clamping cavity and further including said roller means eccentrically connected to said motor means for selectively compressing said first and second means.

6. The apparatus of claim 1 wherein said sensor means includes photodetector means responsive to an optical signal from said channel for producing said output signal.

7. The apparatus of claim 6 wherein said sensor means further includes photoemitter means for directing said optical signal having a predetermined intensity into said channel, a predetermined change of the intensity of said optical signal from said channel being indicative of when said trailing interface is at said second position in said channel.

8. The apparatus of claim 1 wherein said sensor means includes photodetector means responsive to an optical signal from said channel for producing a second output signal indicative of a bubble in said blood.

9. The apparatus of claim 8 wherein said control means includes means responsive to said second output signal for determining a quantity for said bubble.

10. The apparatus of claim 1 wherein said sensor means includes photodetector means responsive to an optical signal from said channel for producing a second output signal indicative of particles in said blood.

11. The apparatus of claim 9 wherein said control means includes means responsive to said second control signal for determining a quantity for said particles.

12. The apparatus of claim 1 wherein said control means includes timer means for determining a time period initiated by said indication of when said trailing interface is produced and terminated by said output signal and further including processor means utilizing said predetermined algorithm and said indication of said volume and responsive to said time period for calculating said blood flow rate.

13. The apparatus of claim 12 wherein said control means includes means responsive to said second output signal for determining a quantity for said pulsating blood flow.

14. The apparatus of claim 1 wherein said sensor means includes photodetector means responsive to an optical signal from said channel for producing a second output signal indicative of pulsating flow of said blood.

15. The apparatus of claim 14 further comprising display means for displaying a frequency for said pulsating blood flow.

16. The apparatus of claim 14 wherein said control means includes memory means for storing a plurality of said time periods and wherein said processor means utilizes a second predetermined algorithm and said indication of said volume and is responsive to said time periods for calculating an average blood flow rate.

17. The apparatus of claim 1 further comprising means for determining the amount of said other fluid delivered to said channel.

18. The apparatus of claim 14 further comprising sensor means for detecting a delivery of said other fluid to said channel.

19. For use with an extracorporeal blood therapy instrument, apparatus for determining a rate of flow of blood in a channel, comprising:

said channel having a predetermined volume between first and second predetermined positions therein;

a first flexibly resilient tube for transporting said blood;

a second flexibly resilient tube for transporting another fluid;

a connector connected to said first and second tubes and said channel for inserting a bolus of said other fluid into said blood for producing an interface at said first predetermined position in said channel;

a clamp unit including an electric motor under control of a processor and a roller eccentrically connected to said motor for selectively occluding said flow of said blood and a flow of said other fluid in said first and second tubes for producing said bolus of said other fluid;

a laser for directing an optical signal having a predetermined intensity into said channel at said second predetermined position;

a first photodetector responsive to said optical signal transmitted through said channel at said second predetermined position for producing a first output signal indicative of when said interface is thereat and a second output signal indicative of bubbles in said blood;

a second photodetector responsive to said optical signal reflected from said channel for producing a third output signal indicative of particles in said blood and a fourth output signal indicative of a pulsating flow of said blood;

a timer circuit for determining a time period initiated by an indication of when said interface is produced and terminated by said first output signal;

a processor utilizing a predetermined algorithm and an indication of said volume and responsive to said time period for calculating said blood flow rate;

said processor being further responsive to said second through fourth output signals for determining a quantity for said bubbles, said particles, and said pulsating blood flow, respectively; and

a display unit for visually displaying said blood flow rate and said quantity of said bubbles, said particles, and said pulsating blood flow.

20. For use with an extracorporeal blood therapy instrument, method for determining a rate of flow of blood in a channel, comprising:

producing a trailing interface of another fluid and between said blood and said another fluid at a first predetermined position in said channel and a first indication of a production of said trailing interface;

producing a second indication of when said trailing interface is at a second predetermine position in said channel, said channel having a predetermined volume between said first and second positions; and

calculating said rate of said flow of said blood in said channel utilizing a predetermine algorithm, said first and second indications, and an indication of said predetermined volume.

21. The method of claim 20 wherein calculating said blood flow rate includes determining a time period between said first and second indications and calculating said blood flow rate utilizing said determined time period.

22. The method of claim 21 further comprising producing a plurality of said trailing interfaces and indications thereof, producing indications of when each of said trailing interfaces is at said second position in said channel, determining a plurality of time periods each between the production of said each trailing interface and a determination of when said each trailing interface is at said second position, and calculating an average rate of said flow of said blood in said channel utilizing a second algorithm utilizing said channel volume and said plurality of time periods.

23. The method of claim 20 wherein producing said trailing interface includes selectively administering a bolus of said other fluid to said blood.

24. The method of claim 20 wherein producing said trailing interface includes transporting said blood in a first resilient flexible tube and said other fluid in a second resilient flexible tube;

interconnecting said first and second tubes with said channel; and

selectively occluding said blood flow and a flow of said other fluid in said first and second tubes, respectively.

25. The method of claim 20 wherein producing said second indication includes directing an optical signal having a predetermined intensity into said channel at said second position and sensing a predetermined change in the intensity of said optical signal from said channel.

26. The method of claim 20 further comprising visibly displaying said blood flow rate when calculated.

27. For use with an extracorporeal blood therapy instrument, apparatus for determining a rate of flow of blood through a channel, comprising:

first means for transporting said blood, second means for transporting another fluid, and connector means for inserting a bolus of said other fluid into said blood for producing an interface between said blood and said other fluid at a first predetermined position in said channel;

sensor means for producing an output signal indicative of when said interface is at a second predetermined position in said channel, said channel having a predetermine volume between said first and second predetermined positions;

control means utilizing a predetermined algorithm and an indication of said volume and responsive to said output signal and an indication of when said interface is produced for calculating said blood flow rate through said channel; and

clamp means under control of said control means for selectively occluding said flow of said blood and a flow of said other fluid in said first and second means, respectively.

28. The apparatus of claim 27 wherein said clamp means includes a clamping cavity and electric motor means under control of said control means for operating roller means in said clamping cavity and further including said roller means eccentrically connected to said motor means for selectively compressing said first and second means.

29. For use with an extracorporeal blood therapy instrument, apparatus for determining a rate of flow of blood through a channel, comprising:

delivery means for producing an interface between said blood and another fluid at a first predetermined position in said channel;

sensor means for producing an output signal indicative of when said interface is at a second predetermined position in said channel, said channel having a predetermined volume between said first and second predetermined positions;

control means utilizing a predetermine algorithm and an indication of said volume and responsive to said output signal and an indication of when said interface is produced for calculating said blood flow rate through said channel; and

means for determining the amount of said other fluid delivered to said channel.

30. For use with an extracorporeal blood therapy instrument, method for determining a rate of flow of blood in a channel, comprising:

producing an interface between said blood and another fluid at a first predetermined position in said channel and a first indication of a production of said interface, said producing including transporting said blood in a first resilient flexible tube and said other fluid in a second resiliently flexible tube interconnecting said first and second tubes with said channel, and selectively occluding said blood flow and a flow of said other fluid in said first and second tubes, respectively;

producing a second indication of when said interface is at a second predetermine position in said channel, said channel having a predetermined volume between said first and second positions; and

calculating said rate of said flow of said blood in said channel utilizing a predetermined algorithm, said first and second indications, and an indication of said predetermined volume.