Device comprising liner for protecting fluid sensitive medicament

• US 4,996,060 A
• Filed: 04/06/1989
• Issued: 02/26/1991
• Est. Priority Date: 03/25/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Cortese, Richard, Magruder, Judy A., Eckenhoff, James B., Wright, Jeremy C., Peery, John R.
• Primary Examiner(s): Cashion, Jr., Merrell C.
• Assistant Examiner(s): HORNE, LEON
• Application Number:
  US07/334,251
• Time in Patent Office: 691 Days
• Field of Search: 424/472, 424/473, 424/468
• US Class Current: 424/473
• CPC Class Codes: A61K 38/27 Growth hormone [GH], i.e. somatotropin
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the device and means in the space for shielding the beneficial agent from fluid.

Claims

1. A device for delivering a beneficial agent to an environment of use, wherein the device comprises:

(a) a wall comprising in at least a part a composition permeable to the passage of aqueous fluid, which wall surrounds;

(b) an internal space;

(c) a beneficial agent in the internal space;

(d) a pharmaceutically acceptable carrier for the beneficial agent in the internal space;

(e) a liner comprising a composition substantially impermeable to the passage of aqueous fluid, said liner in the internal space that surrounds the area initially occupied by the beneficial agent for substantially preventing the passage of fluid into the internal space whereby the beneficial agent is substantially shielded from fluid contact;

(f) means in the internal space for displacing the beneficial agent from the device; and

,

(g) means in the wall connecting the exterior of the device with the internal space for delivering the beneficial agent to the environment of use.

2. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein the beneficial agent is a hormone.

3. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein the device is an implant.

4. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein the beneficial agent is somatotropin.

5. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein the liner comprises a coat in contact with the inside wall, which coat substantially shields the beneficial agent from aqueous fluid contact.

6. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein a layer comprising a composition substantially impermeable to the passage of aqueous fluid is between the beneficial agent and the means for displacing the beneficial agent.

7. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein the device is adapted as an implant for livestock.

8. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein the liner comprises a polycarbonate.

9. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein the environment of use is a pig.

10. The device for delivering the beneficial agent to the environment of use according to claim 1, wherein histidine is present in the internal space.