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Non-radioactive nucleic acid hybridization probes

  • US 4,996,142 A
  • Filed: 09/04/1987
  • Issued: 02/26/1991
  • Est. Priority Date: 09/04/1986
  • Status: Expired due to Fees
First Claim
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1. An adduct of a basic macromolecule and biotin having the formula:

  • ##STR5## wherein MM is the residue of a basic macromolecule selected from the group consisting of cytochrome C, histone and polyethyleneimine, formed by substituted the H-atom of one or more primary or secondary amino groups;

    alk represents an alkylene group having from 1 to 10 C-atoms;

    m is 0 or 1, and n is a positive integer from 1 to 30, with the proviso that, where MM represents cytochrome C or histone, m is not zero.

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